Objectives: This study aims to evaluate the enrichment of molecular pathways related to human body response to chemical stress and ROS generation in primary Sjgren's syndrome (pSS), systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Methods: A PBMC expression database for several ...
genistein-inhibited cells showed no response to the external stimulus and change in sensor signal was not measured. NWFETshave demonstrated ability to detect extracellular acidification of approximately 200 cells, with a potential for further optimization and lower detection limit, even at the single cel...
Furthermore, the cellular response in PCLS was also determined after incubation with bacterial lipopolysaccharides (LPS) in the incubation medium, which enables further comparisons to the nerve agent-specific effects (Fig. 1). LPS was chosen since it is a potent innate immune stimulus commonly ...
The GPEA of the S. cerevisiae GRN-TRN interface comprises 39 terms with pfdr≤0.01 (Figure4B). The processes involve the positive regulation of metabolic and biosynthetic processes (RNA), regulation of gene expression, galactose and alcohol metabolic process and response to chemical stimulus. The ...
These signals can be used to study the cellular response to physical or chemical external stimuli. The response reflects in turns the metabolic activities of the cell and gives us a quantitative measure of the viability of the cellular specimen5. The nanosensor can be used to study cellular ...
muscle cells in the body contract in response to a nerve’s electrical pulse. Electrically stimulating muscle cells in the lab, however, could potentially damage them, so the team chose to genetically manipulate the cells to contract in response to a noninvasive stimulus — in this case, blue...
Cells typically respond to chemical or physical perturbations via complex signaling cascades which can simultaneously affect multiple physiological parameters, such as membrane voltage, calcium, pH, and redox potential. Protein-based fluorescent sensors can report many of these parameters, but spectral overl...
The secretory response of the mast cell to clustering of its surface membrane receptors for Fcε domains of IgE (Type 1 Fcε receptors — FcεRI) has long been recognized as an instructive paradigm for stimulus-secretion coupling mechanisms (Froese...
The body’s defense mechanisms initiate inflammation as an adaptive response to harmful stimuli, such as infections and tissue damage.78The inflammatory response is a tightly regulated and precise process. Upon exposure to a harmful stimulus, the first step is detecting the stimulus via cell surface...
3.1.1. Extrinsic Factors Chemical Substances Twelve studies explored the impact of preconditioning MSCs derived from adipose tissue or bone marrow with chemical substances. The various chemical agents used in these studies share the ability to promote increased survival of MSCs, neuroprotection, and ...