The angle of cell orientation varied in direct relation to the stretching amplitude and became steeper with increasing intensity of the mechanical stimulus. For instance, by use of a stretching amplitude of 15%,
1.5Cell response Cellular responseto materials is dependent on the surrounding interactive environment of mechanical, physicochemical and topographical stimuli (Wonget al., 2004). Further studies are required on the effects ofmechanical stimuli on cell performance. Cell–material adhesion is influenced by...
Furthermore, it was confirmed that the osteoblasts were desensitized to mechanical stimulus. Consecutive stimulation of the MC3T3-E1 cells with FSS failed to elicit a [Ca2+ ]i response during the 2nd stimulation. By measuring the [Ca2+ ]i response to ATP and BzATP, it was determined that ...
Here we investigate how communication between extracellular stress and chromatin structure may regulate cellular mechanical behaviors. We demonstrate that histone H1.0, which compacts nucleosomes into higher-order chromatin fibers, controls genome organization and cellular stress response. We show that ...
“cellular response to growth factor stimulus” in ECTOs (Fig.2C). To further characterize the pluripotency stage of bovine embryonic development, we analyzed the activity of signaling pathways related to pluripotency during epiblast development. We observed a downregulation of genes related to the ...
muscle cells in the body contract in response to a nerve’s electrical pulse. Electrically stimulating muscle cells in the lab, however, could potentially damage them, so the team chose to genetically manipulate the cells to contract in response to a noninvasive stimulus — in this case, blue...
However, given that all life on Earth has evolved under the persistent influence of the planet’s gravitational vector, it is important to consider if mechanical signalling via MA channels will be impacted in reduced gravitational environments, such as the microgravity (1 ×10-3 to 1 ×10-5 ...
Light is considered as an external stimulus to plant cells. The photosynthetic light response is an important process that allows plants to optimize the efficiency ofphotosynthesis, which is the core technology for green energy. However, currently, little is known about the molecular mechanisms behind...
A cell must be able to respond, then desensitize to a mechanical stimulus, just as a receptor may desensitize to a ligand. Therefore, "stop," or inhibitory signals, are perhaps as important as "go," or stimulatory signals with respect to a mechanical load response. A cell must be able ...
Temporal and spatial changes in the cytoskeletal protein configuration due to mechanical stimulation have been detected and characterized by a wide range of biophysical techniques, including magnetic twisting, magnetic tweezer, traction microscopy, atomic force microscopy, nanoscale particle tracking, and ...