The present invention relates to novel uses of xanthine derivatives, more particularly pentoxiffyline, derivatives or metabolites thereof, alone or in combination with cytochrome P450 inhibitors, such as e.g. ciprofloxacin. They may be used for treating tumors, hormone-related disorders, neurological ...
The main focus of this work was placed on the genes belonging to "Response to estradiol", "Response to follicle-stimulating-hormone", "Cellular response to hormone stimulus", "Cellular hormone metabolic process" and "Hormone biosynthetic process" gene ontology groups. These groups of genes have ...
To gain further insights into the existence of the naïve, formative, and primed pluripotency stages during epiblast development in bovine embryos and to elucidate the underlying core regulatory signaling pathways involved, we performed pairwise comparisons to classify the 2267 differentially expressed gen...
The body’s defense mechanisms initiate inflammation as an adaptive response to harmful stimuli, such as infections and tissue damage.78The inflammatory response is a tightly regulated and precise process. Upon exposure to a harmful stimulus, the first step is detecting the stimulus via cell surface...
Thus, one or more mechanisms must exist that couple cell-surface stimuli to the transcriptional regulatory apparatus of the neuron. In this article James Morgan and Tom Curran detail a stimulus-transcription coupling cascade, involving the products of the proto-oncogenes, c- fos and c- jun, ...
The body’s defense mechanisms initiate inflammation as an adaptive response to harmful stimuli, such as infections and tissue damage.78The inflammatory response is a tightly regulated and precise process. Upon exposure to a harmful stimulus, the first step is detecting the stimulus via cell surface...
Non-Mammalian Hormone-Behavior Systems Erik C.Johnson, inHormones, Brain and Behavior (Third Edition), 2017 2.21.2.1Stress ‘Sensors’ In a discussion of stress responses, we must first consider the level of biological organization in which the responses to adverse environmental changes originate. ...
Regulation of cellular response to TGFβ stimulus, response to hyperoxia, negative regulation of embryonic development, and negative regulation of G1/S transition of mitotic cell cycle were also enriched terms. For the MM comparison, neuroinflammatory response, regulation of epithelial to mesenchymal ...
L. Brady, A. Lynn, H. Whitfield, et al., “Intrahippocampal colchicine alters hypothalamic corticotropin-releasing hormone and hippocampal steroid receptor mRNA in rat brain,”Neuroendocrinology,55, 121–133 (1992). ArticlePubMedCASGoogle Scholar ...
GnRH is secreted in a pulsatile fashion from the pre-optic area of the hypothalamus. GnRH binds to its receptor on the anterior pituitary to stimulate LH and follicle-stimulating hormone (FSH) release, which induce sex steroid secretion and gametogenesis in the gonads. Once thought to be the ...