Thus, one or more mechanisms must exist that couple cell-surface stimuli to the transcriptional regulatory apparatus of the neuron. In this article James Morgan and Tom Curran detail a stimulus-transcription coupling cascade, involving the products of the proto-oncogenes, c- fos and c- jun, ...
one should consider the factors that could contribute to β-cell heterogeneity. Hence, understanding the process of β-cell development, β-cell interaction with neighbouring cells, and β-cell response to stimulus can open the door to an explanation behind β...
cell differentiation and hormonal stimulation. Specific glycerophosphodiester phosphodiesterases are involved in their catabolism, which, as with their formation, is under hormonal regulation. With their
Cell signaling pathways direct the flow of information (i.e. flux) from an extracellular stimulus to the corresponding cellular response (e.g., cellular proliferation, contact inhibition, or cellular death). By analogy with metabolic control analysis, control of flow of information is distributed ...
Naturally, the subsequent responses to the gravity stimulus differ widely between the systems ranging from orientational movement and directed growth to physiological reactions and adaptation to the environmental conditions.Similar content being viewed by others Gravity sensing in plant and animal cells ...
Inhibition of microRNA-146a in H9C2 cells caused increased TRAP220 expression and more apoptosis under the stimulus of hypoxia and re-oxygenation, while knockdown of the increased TRAP220 expression led to decreased cell apoptosis. Conclusions MicroRNA-146a exerts a protective effect against MIRI, ...
Darcus noted that neuromuscular impulses facilitated synaptic transmission at nerve–muscle junctions (NMJs) and all along the reflex arc, and with sufficient repetition, might reduce resistance to signal transmission from stimulus to contraction. Writing in the context of a raging polio epidemic, ...
ER-associated degradation of misfolded proteins [34,35]. These RNAseq data suggest that the SMDCF stem cells exhibit cell stress in response to the accumulated mutant FN and that this cell stress response is further elevated when the SMDCF stem cells are subjected to a chondrogenic stimulus. ...
including nuclear import of tumor-suppressors like PTEN, nuclear hormone receptors as well as drug export. It is speculated that some of the cargos transported in vault particles are bound to the vault RNAs present in these complexes [66,67,89,90,91]. But up to now, the role of vault pa...
[114]. YAP is a powerful oncogenic stimulus whose overexpression leads to HCC [162]. Insertion of TQ (at a concentration of 10 μM) into HepG2 and Huh7 cells caused the over-expression of both miR-16 and miR-375. Presence of these miRNAs up-regulated caspase-3 and down-regulated Bcl...