mimic the effect of endogenousnucleophilessuch as the GSH:GSSG redox couple that coordinates the homeostatic response to oxidative and reductive stress (Scirè et al., 2019). In this sense, by favoring maintenance of homeostasis, parahormesis would differ from the classical hormesis, that results in...
The inflammatory response is normally thought to be switched on by an antigenic stimulus. However, in certain instances, such as cell injury, pregnancy and tumor growth, sterile inflammation occurs. We have found a protein that responds to cellular stress, the a2 isoform of vacuolar ATPase, and...
This endogenous antigenic stimulus would be strong and temporary, and would lead to the cellular manifestations of the transient humoral immunologic response which are evident in the regressing stroma of these two mammals. This humoral immune reaction may be one of the regulatory mechanisms involved ...
Mice were fed vehicle or PLX5622 starting two weeks before SCI, and then at 2 dpi, coinciding with the normal peak of endogenous CCL2 production31andTlr2expression28,32, vehicle or rCCL2 and TLR2 ag were injected into the injury site in an effort to recruit and then reprogram infiltrati...
miRNAs can be sequestered by other competitive endogenous RNAs that share complementary sequences, ensuring the regulation of translation128. However, many roles of miRNAs in certain physiological processes have not yet been fully elucidated through identification of their cognate partners or cooperative mo...
It is generally admitted that it is the co-ordination of all resulting signals rather than their individual effect that leads to the highly specific pattern of gene expression dictating the cellular response to the initial stimulus. Deciphering the components of these regulatory networks is of ...
Other processesthat are moderately enriched (10-5<p < 0.05) includedgene expression and response to endogenous and exter-nal stimuli such as heat, abiotic stimulus, organic sub-stances, unfolded proteins, and protein stimuli. Five ofthe potentially most significant protease-associated setsof proteins...
Degradation of transgene-coded and endogenous proteins in the muscles of Caenorhabditis elegans To develop reporter systems to study the regulation of protein degradation in innervated muscle, we have used strains of the nematode Caenorhabditis elegan... JL Fostel,LB Coste,LA Jacobson - 《Biochemical ...
(e.g., BCL-2, BCL-XL, and IAPs) are upregulated in cancer cells, thus inhibiting apoptosis and promoting tumor survival. Hence, Smac mimetics have been developed as endogenous proapoptotic therapies in cancer.43Similarly, many other antiapoptotic factors are targeted by anticancer drugs using ...
6b. We next examined the subcellular localization of E2s by consulting the Human Protein Atlas (proteinatlas.org), which reports antibody-based immunostaining of endogenous E2s in HEK293T cells67,68, and additional published datasets69,70, which report the in silico prediction of E2 localization....