In response to extracellular application of 50 microM ATP, all individual porcine aortic smooth muscle cells respond with rapid rises from basal [Ca2+]i to peak [Ca2+]i within 5 s. The time from stimulus to the peak of the [Ca2+]i response increases with decreasing concentration of ATP. ...
Conversely, these cells cannot respond to a surface-bound gradient of extracellular matrix (haptotaxis). Consistent with this finding, cells depleted of Arp2/3 fail to globally align focal adhesions, suggesting that one principle function of lamellipodia is to organize cell-matrix adhesions in a ...
Objective infrared recording devices were used to measure simultaneously and continuously both accommodation and accommodative vergence to near stimuli in 4 subjects with intermittent exotropia of the divergence-excess type (2 simulated and 2 true). In addition standard clinically determined stimulus accommo...
Stimulus-secretion coupling is normally initiated by an extracellular signal in the form of a hormone or a neurotransmitter binding to a specific receptor site on the outer surface of the gland cell membrane. Several membrane transduction mechanisms exist, but with regard to stimulus-secretion coupling...
This study investigated olfactory processing in a functional context by examining the responses of single avian olfactory bulb neurones to two biologically important gases over relevant concentration ranges. Recordings of extracellular spike activity were made from 80 single units in the left olfactory bul...
(Fig.1a,b). Previous studies showed that the length of primary cilia in different types of cells changed in response to extracellular stimuli39,40,41. To examine if primary cilia in NP cells respond to extracellular osmotic stimulus, we cultured NP cells under different osmotic conditions and ...
(Supplementary Fig.S5). In the cellular component, more transcripts were categorized in the "extracellular region" and "cytoplasm" (Supplementary Fig.S5). To get more insight into the function of lncRNA.2-FL targets, online KEGG automatic annotation server (KAAS) was used for target genes in...
For biological process, the significantly enriched DEGs were mainly involved in ‘response to stimulus’ (GO:0050896), ‘organonitrogen compound metabolic process’ (GO:1901564), ‘response to stress’ (GO:0006950), and ‘protein metabolic process’ (GO:0019538). These results indicated that the ...
Extracellular recording of the responses of cat retinal ganglion cells to narrow moving bars revealed systematic response variations with changes in stimulus velocity. These response variations were studied by collecting peri-stimulus histograms from brisk-sustained (X) and brisk-transient (Y) ganglion ce...
Our aim was to explore the functions of SII by comparing response properties of whisker-related neurons in this area with their counterparts in the SI. We obtained extracellular unit recordings from narcotized rats, in response to whisker deflections evoked by a piezoelectric device, and compared ...