In the U-937 cells treated with DZA, cytochrome c release from mitochondria and subsequent activation of caspase-9, -8 and -3 were observed before the induction of apoptosis. zDEVD-Fmk, a specific inhi- bitor of caspase-3, and zLEHD-Fmk, a specific inhib- itor of caspase-9, ...
When compared with chloride and bromide, the higher electronegativity fluoride substituted derivatives significantly enhanced mitochondrial apoptosis pathway by remarkably increasing the expression of caspase-9 in HeLa cells. The current findings would stimulate an enormous amount of research directed toward ...
KaplanMeier survival curves demonstrated that the patients with low caspase-9 expression showed significantly shorter survival (p < 0.05) than those with high caspase-9 expression. These findings suggest that immune clearance gastric carcinoma cells in ascites activated by caspase-9 helped to improve ...
Caspase-9 Activation—Critical for Betulin-induced Apoptosis of Human Hepatoma Cells Support info 《Chemical Research in Chinese Universities》 - 0 - 被引量: 0 Protection of betulin against cadmium-induced apopto...
Here, we test the hypothesis that expression of a caspase-based artificial death switch in tumor-associated endothelial cells will disrupt tumor blood vessels and slow down tumor progression irrespective of tumor type. Adenoviral vectors expressing inducible Caspase-9 (iCaspase-9) under transcriptional ...
iCaspase-9withthedimerizerdrugAP20187.LocaldeliveryofAd-hVEGFR2-iCaspase-9followedbyintraperitonealinjectionofAP20187ablatedtumormicrovesselsandinhibitedxenograftedtumorgrowthinalltumormodelsevaluatedhere.Weconcludethatacancergenetherapystrategybasedonatranscriptionallytargetedviralvectorexpressinganinduciblecaspaseallowsfor...
CD19 expression and suicide gene function in both reactivated and nonreactivated cells were measured on day 24 or 25 post transduction. In some experiments we also cultured the cells for 3 weeks post transduction but simulated them with 30 Gy-irradiated allogeneic PBMC at responder:stimulator ratio...
When cells were pretreated with Z-IETD-fmk, a caspase 8 specific inhibitor, the activation of caspase 3 and caspase 9 were significantly delayed. Finally, we found that Bax did not translocate from the cytosol to the mitochondrial membrane during H2O2-induced apoptosis. Our results suggest that,...
is the first to apply mass cytometry to examine expression of 35 receptors on peripheral blood NK cells in healthy donors, including monozygotic twins, and found incredibly high diversity with up to 30,000 different NK cell clones within an individual, based on unique receptor expression phenotypes...
High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA sensing in tumor cells after radiation is rather limited. Here we demonstrate that irradiated tumor cells hijack caspase 9 signaling to suppress ...