Caspase-9RNA interferenceIn the intrinsic apoptosis pathway, mitochondrial disruption leads to the release of multiple apoptosis signaling molecules, triggering both caspase-dependent and -independent cell death. The release of cytochrome c induces the formation of the apoptosome, resulting in caspase-9 ...
In contrast to the canonical role of caspase-9 as an initiator of apoptosis, RVO-induced activation of endothelial caspase-9 is not associated with endothelial cell death. The unexpected link of endothelial caspase signaling to neuronal function provides insights into neurovascular biology and ...
Ac-LEHD-pNA(Caspase 9显色底物)是caspase 9的显色底物，Ac-LEHD-pNA可被caspase 9催化产生黄色的pNA(p-nitroaniline)，从而可以通过测定吸光度来检测caspase 9的活性。Caspase(Cysteine-requiring Aspartate Protease)是一个在细胞凋亡过程中起重要作用的蛋白酶家族。pNA在405nm附近有强吸收。Caspase 9也称ICE-LAP6...
《Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-4β signaling pathway》 作者:Baoquan Li,Xiaoguang Li 期刊:Biomedicine & Pharmacotherapy 影响因子:3.743 PMID:30142548 ...
In human cells, phosphorylation of caspase-9 at Thr125 is catalyzed by CDK1- cyclin B1 to attenuate apoptotic cell death during mitotic arrest. Interestingly, ERK1⁄ 2 can also target this site to initiate growth fac- tor signaling. Additionally, DYRK1A can also participate in the process ...
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遵义医学院硕士学位论文凋亡调控因子Cyto-C、Caspase-3和Caspase-9在乳腺癌中的表达及其意义姓名:***学位级别:硕士专业:病理学指导教师:**20040522遵义医学院2004届硕士学位论文英文缩写索弓Cyto～CCaspaseDCISIDCApaf—l删ECsIHCPTAIFCytochromeC细胞色素CCysteiny]aspartatespecificprotease半胱氨酰天冬氨酸酶Ductalcarcin...
Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase 9 promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner, and proteolytically cleaves poly(ADP- ribose) polymerase (PARP). Caspase 9 is expressed in ...
【13】Sheng M, et al. Caspase-6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver. Cell Death Discov. 2023 Mar 28;9(1):106. 【14】Fritsch M, et al. Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature....
Ac-LEHD-pNA(Caspase 9显色底物)是caspase 9的显色底物,Ac-LEHD-pNA可被caspase 9催化产生黄色的pNA(p-nitroaniline),从而可以通过测定吸光度来检测caspase 9的活性。Caspase(Cysteine-requiring Aspartate Protease)是一个在细胞凋亡过程中起重要作用的蛋白酶家族。pNA在405nm附近有强吸收。