Ac-LEHD-pNA(Caspase 9显色底物)是caspase 9的显色底物，Ac-LEHD-pNA可被caspase 9催化产生黄色的pNA(p-nitroaniline)，从而可以通过测定吸光度来检测caspase 9的活性。Caspase(Cysteine-requiring Aspartate Protease)是一个在细胞凋亡过程中起重要作用的蛋白酶家族。pNA在405nm附近有强吸收。Caspase 9也称ICE-LAP6...
《Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-4β signaling pathway》 作者:Baoquan Li,Xiaoguang Li 期刊:Biomedicine & Pharmacotherapy 影响因子:3.743 PMID:30142548《Decreased circular RNA hsa_circ_0001649 ...
cell apoptotic processcellular response to UVsignal transduction in response to DNA damagepositive regulation of neuron apoptotic processresponse to antibioticcellular response to dexamethasone stimulusextrinsic apoptotic signaling pathway in absence of ligandregulation of response to DNA damage stimulusactivation...
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Caspase-9被称为“始发性”或“初始”Caspase,因为它在一系列细胞凋亡信号传导途径中起始活化,是细胞凋亡信号的重要节点。在细胞凋亡途径中,Caspase-9的激活通常是通过形成一个Caspase-9异二聚体的方式进行的。这种二聚体形成后,Caspase-9会被进一步激活,从而开始进一步激活下游的执行Caspase(如Caspase-3和Caspase-7...
In contrast to the canonical role of caspase-9 as an initiator of apoptosis, RVO-induced activation of endothelial caspase-9 is not associated with endothelial cell death. The unexpected link of endothelial caspase signaling to neuronal function provides insights into neurovascular biology and ...
Front. Cell. Infect. Microbiol 2019 因此,caspase-8是细胞死亡的中心调节因子,根据其翻译后状态和细胞类型,促进其凋亡、坏死或焦亡。caspase-8以外的调节因子已经成为细胞死亡途径之间的守门人。例如,GBP1最近被提出作为一种微生物特异性开关,能够识别弓形虫DNA,通过AIM2诱导细胞凋亡,或沙门氏菌凋亡,而不是通过casp...
Cell Death Differ, 2015, 22(5):719-730. [14]DORSTYN L, HACKETT-JONES E, NIKOLIC A, et al. Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal ...
In human cells, phosphorylation of caspase-9 at Thr125 is catalyzed by CDK1- cyclin B1 to attenuate apoptotic cell death during mitotic arrest. Interestingly, ERK1⁄ 2 can also target this site to initiate growth fac- tor signaling. Additionally, DYRK1A can also participate in the process ...
细胞色素C结合并激活Apaf-1以及procaspase-9,形成“凋亡小体”。这些凋亡线粒体事件的控制和调节通过Bcl-2蛋白家族的成员发生。肿瘤抑制蛋白p53在调节Bcl-2蛋白家族中具有关键作用。 The two most widely characterised apoptotic pathways are the Intrinsic and Extrinsic pathways. The extrinsic signaling pathways ...