ECM (extracellular matrix) development allows to obtain cell‐cell and ECM‐cell interactions in cultures [52]. Using 2‐D cell cultures, the researchers were not able to mimic in vivo state. The classical monolayer cultures have various limitations, for example, loss of tissue specific architectu...
Cell-cell interactions in normal heart. The cardiomyocytes (CMs), cardiac fibroblasts (CFs), endothelial cells (ECs) and macrophages interact with each other via paracrine, direct interaction, and ECM in normal heart Full size image Cardiomyocytes are pivotal for the heart’s systolic and diastolic...
These data confirm that cell-cell interactions can play an important role in promoting the expression of αSMA during TGFβ1-induced EMT and suggest that a threshold cell spread area may be necessary for cell-cell interaction induced αSMA. Direct cell-cell contact mediates αSMA ...
(i) cell adhesion/de-adhesion during migration mostly involves interactions via integrin and proteoglycan receptors and their association with cytoskeletal elements; (ii) expression of specific genes during differentiation involves interaction with basement membrane components via integrin recptors and with ...
Integrins, via interaction with the extracellular matrix (ECM), control cell adhesion and motility. The two systems are functionally linked because uPAR and PAI-1 bind to the ECM component vitronectin (VN). Because integrin signaling ... S Hapke,H Kessler,NA De Prada,... - 《Journal of Bio...
1D). The increased fiber density between cell pairs in comparison to single cells could potentially be used to quantitatively decouple the contribution of the interaction of the cell with the ECM (cell-ECM) and the mechanical information transmitted from the communicating partner (cell-ECM-cell) ...
The survival and colonization of of disseminated tumor cells (DTCs) within the bone metastatic microenvironment heavily rely on cell adhesion, which is facilitated by the interaction of various adhesion molecules. For instance, tumor cells express integrin αvβ3, enabling adhesion to extracellular matr...
In the next section, the main components of cell-ECM interaction as well as the implicated mechanisms are reviewed. Also, some of the most important features of cell-biomaterial interaction in the framework of tissue engineering are considered in section 2.4. 2. Mechanisms for Cell-ECM and ...
suggests also a non-classical role on maturation of female gametes, on cell adhesiveness and interaction, on differentiation, on secretion and apoptosis ... M Caterina,PM D'Agati,V Mansueto,... - 《Caryologia》 被引量: 6发表: 2006年 Cell-cell and cell-extracellular matrix interactions regulate...
In each category, the extent of cell–cell contact and cell–ECM interaction can vary based on the encapsulation method and the characteristics of the biomaterials (Figure 1). Figure 1. Three types of cell encapsulation according to the thickness of the encapsulation wall and cellularity. ...