Remodeling of the heart involves cellular and acellular components.Cell–cell and cell–ECM interactions are required for normal cardiac function.Cell communication involves chemical, mechanical and electrical signaling.Better understanding of cell interactions can lead to novel therapies...
Different variants of cell culture found application in modeling diseases, IVF technology, stem cell and cancer research, monoclonal antibody production, regenerative medicine and therapeutic protein production. All those different scientific approaches would not be possible without some crucial discoveries ...
Cell-cell interactions in normal heart. The cardiomyocytes (CMs), cardiac fibroblasts (CFs), endothelial cells (ECs) and macrophages interact with each other via paracrine, direct interaction, and ECM in normal heart Full size image Cardiomyocytes are pivotal for the heart’s systolic and diastolic...
Integrin-mediated adhesion of epithelial cells to extracellular matrix (ECM) proteins induces prolonged tyrosine phosphorylation and partial activation of ... HM Bill,B Knudsen,SL Moores,... - 《Molecular & Cellular Biology》 被引量: 275发表: 2004年 Integrin αvβ3/Vitronectin Interaction Affects ...
细胞外基质（Extracellular matrix，ECM）的过度沉积是纤维化组织的一个重要病理特征，而ECM的降解在纤维化消退过程中不可或缺。具有ECM降解能力的细胞已成为纤维化疾病的一种新兴治疗工具。近日，清华大学医学院杜亚楠课题组在Cell Regeneration上发表了题为“Cell mediated ECM-degradation as an emerging tool for anti...
这项研究将为推进凝胶微球系统在细胞培养和组织再生方面的应用提供有力的证据支撑。相关工作以“Gel microspheres enhance the stemness of ADSCs by regulating cell-ECM interaction”发表于《Biomaterials》杂志上。 论文研究内容摘要示意图 ...
癌细胞还可通过特异性免疫和基质细胞介导的,或改变细胞外基质(ECM)来重塑TME,从而阻碍免疫效应细胞招募至TME,以此进行伪装。 TME的三个主要细胞群,癌症相关成纤维细胞(CAF)、肿瘤相关巨噬细胞(TAM)和肿瘤相关中性粒细胞(TAN)积极促进排斥,从而对基于ICI的免疫疗法产生抵抗。此外,WNT和CDK4/6信号传导也参与了免疫效应...
图5 ECM和细胞黏连相关基因的表达 小结 1)84%的新生PC区肝细胞由损伤区域周围残余的CYP2E1+肝细胞增殖而来,只有16%的肝细胞由先前未受损伤的PP肝细胞贡献。mTOR/4EBP-1信号通路以及LDHA表达上调显著参与了调控PC区肝细胞的再生。 2)在肝再生过程中,髓系来源的免疫细胞动态性被招募到损伤区域,且损伤区域存在肝...
Therefore, a concise understanding of cell-biomaterial interaction includes a deep understanding of cell biology and cell-extracellular matrix interaction, to be extrapolated to the biomaterial surface for tissue engineering applications. In this section, the main functions and structures of the cell, as...
The cell–cell interaction analysis based on the ligand–receptor interactions between ESCs, EECs, and lymphocytes was conducted using CellChat v1.4.0 [85]. CellChat was used to derive a communication probability value for each ligand–receptor pair based on the average expressions of a ligand in...