Cell-extracellular matrix (ECM) detachment is known to down-regulate ERK signalling, an intracellular pathway that is central for control of cell behaviour. How cell-ECM detachment is linked to downregulation of ERK signalling, however, is incompletely understood. We show here that focal adhesion pr...
We provide evidence that integrin-mediated cell-extracellular matrix (ECM) adhesion modulates the transmission of apically generated tension during dorsal closure (DC) in Drosophila. Integrin-containing adhesive structures resembling focal adhesions were identified on the basal surface of the amnioserosa (...
p pBackground/p pInteractions of cells with the extracellular matrix (ECM) are critical for the establishment and maintenance of stem cell self-renewal and differentiation. However, the ECM is a complex mixture of matrix molecules; little is known about the role of ECM components in human ...
The extracellular matrix (ECM) provides the principal means by which mechanical information is communicated between tissue and cellular levels of function. These mechanical signals play a central role in controlling cell fate and establishing tissue structure and function. However, little is known regardi...
Cell-matrix interactions or disruption affects the cell cycle regulation in various ways. In this study, Clara cells obtained form both wild type (wt) and p21 knockout (p21 ko) mice were isolated and cultured on different ECM combinations. Different ECM compositions did not influence Clara cells...
Extracellular matrix (ECM) mechanical cues have powerful effects on cell proliferation, differentiation and death. Here, starting from an unbiased metabolomics approach, we identify synthesis of neutral lipids as a general response to mechanical signals
Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metabol...
Cell invasion into the 3D extracellular matrix (ECM) is a multistep biophysical process involved in inflammation, tissue repair, and metastatic cancer invasion. Migrating cells navigate through tissue structures of complex and often varying physicochemical properties, including molecular composition, porosity...
Proteolysis of the extracellular matrix (ECM) results in thecreation of haptotactic gradients which cells use to move in a directed fashion. The proteolytic creation of these gradients also results in the production of digested fragments of ECM. In this study we show that in the human ...
Original transplantation experiments implicated the extracellular matrix (ECM) as a pivotal factor in the regulation of this process, and subsequent in vitro and in vivo studies have uncovered a number of ECM molecules potentially responsible for the NC cell–ECM interaction. Recent genetic ...