Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis 细胞外基质动脉粥样硬化血管疾病高血压合成细胞结构生物利用度ECM在脉管的网络以内的细胞外的矩阵(ECM ) 两个都提供一个结构,规章的角色.ECM 是一动态形成在网络以内连接房间的结构的多重蛋白质合成.血容器被血压扩张并且因此,还与...
Fat storing cells (FSC) are nonparenchymal liver cells generally considered the major source of the hepatic extracellular matrix (ECM). Transforming growth factor beta 1 (TGF-beta 1) is a potent regulator of ECM synthesis in various cell types. In this study, the effect of TGF-beta 1 on ...
The communication of cells with their surroundings is mostly encoded in the epitopes of structural and signalling proteins present in the extracellular matrix (ECM). These peptide epitopes can be incorporated in biomaterials to serve as function-encoding molecules to modulate cell–cell and cell–ECM ...
Both type I and type II pulmonary epithelial cells contact the extracellular matrix (ECM). Type II cell-ECM interactions are bidirectional; they involve matrix-mediated modulation of type II cell differentiation, as well as cellular synthesis and deposition of ECM components. The present experiments ...
2.6The Extracellular Matrix Theextracellular matrix(ECM) is a non-cellular macromolecular 3-D network structure, composed of elastin, fibronectin, laminins, proteoglycans/glycosaminoglycans and other glycoproteins, as well as numerous soluble factors(67). The matrix components bind to each other and to...
Production of extracellular matrix (ECM) by mesangial cells (MCs) contributes to progressive glomerulosclerosis. Our previous immunocytochemical studies on ECM production by MCs [1] were extended by examining the gene expression and protein synthesis using Northern blotting and ELISA. ELISA demonstrated th...
Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells Extracellular matrix (ECM) provides several structural and functional characteristics to tissues including cell support, mechanical integrity and biologica... Vishal Gupta and K. Jane Grande-Allen - 《...
Special attention is directed to a crucial aspect of matrix biology: cell-matrix interactions. A number of cell membrane receptors were recently described mediating the two way information flow from the cells to the matrix via the 'programme' of ECM synthesis coded in the genome and unfolding ...
matrix in response to a chemokine gradient. While microfluidic devices have been developed for this purpose11, they commonly incorporate hydrogels based on natural ECM proteins, in particular, type I collagen and fibrin, which do not allow independent control over matrix properties12. In addition, ...
We investigate if CsA affects cell turnover and extracellular matrix (ECM) synthesis and degradation in MC3T3-E1 osteoblasts, as a surrogate model for in vivo events.Cells were exposed to increasing doses of CsA (0, 0.5, 1 and 5 microg/ml). Proliferation was evaluated by bromodeoxyuridine (...