Given that different cell death modalities may be dysregulated in different diseases, it is becoming increasingly clear that such assays need to not only quantify the extent of cell death, but they must also be able to distinguish between the various pathways. Here, we systematically describe ...
Cell death assays for drug discovery 来自 Springer 喜欢 0 阅读量: 129 作者:O Kepp,L Galluzzi,M Lipinski,J Yuan,G Kroemer 摘要: Cell death has an important role in many human diseases, and strategies aimed at modulating the associated pathways have been successfully applied to treat various ...
Dysregulated cell death occurs in many human diseases, and modulating the associated pathways has proved effective in the treatment of cancer, stroke and neurodegenerative disorders. In their review, Kepp and colleagues provide an overview of assays capa
is thecell deathmechanism. Typically, assays are chosen that evaluate an early and a late apoptotic event. These experiments evaluate cytomorphological alterations, measure DNA fragmentation, detect caspases, cleaved substrates, regulators, inhibitors, membrane alterations, and employ mitochondrial assays. ...
2024Cell Death Discovery doi:10.1038/s41420-024-02177-ypmid:39284830 Derangements in protein homeostasis and associated proteotoxicity mark acute, chronic, and drug-induced hepatocellular injury. Metabolic dysfunction-associated proteasomal inhibition and the use of proteasome inhibitors often underlie such ...
Ubiquitination in the regulation of inflammatory cell death and cancer. Cell Death Differ. 2021;28(2):591–605. Article CAS PubMed PubMed Central Google Scholar Cervia LD, Shibue T, Borah AA, Gaeta B, He L, Leung L, et al. A Ubiquitination Cascade regulating the Integrated Stress ...
is widely found in South America and empirically used in Brazil for the treatment of several diseases, mainly cancer. The aim of the study was to investigate cell death mechanisms induced by Synadenium umbellatum Pax. using Ehrlich ascites tumor (EAT) cells, as well as the myelotoxicity ...
WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer. Theranostics. 2021;11(10):4809–24. Article CAS PubMed PubMed Central Google Scholar Cheng B, Tang C, Xie J, Zhou Q, Luo T, Wang Q, Huang H. Cuproptosis illustrates tumor micro-...
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