梅斯小编将以近日一篇发表在Nature出版集团旗下刊物《Cell Death Discovery》,题为“Theinhibition of FKBP5 protects β-cell survival under inflammation stress viaAKT/FOXO1 signaling”的研究论文为例,来解读急性炎症应激下胰岛β细胞与自噬相关联的研究思路,强强联合自然能斩获高分期刊!这篇研究,揭示了FKBP5在β细...
近日,来自法国的研究员们在Nature出版集团旗下刊物《Cell Death Discovery》发表了题为“miR-218-5p and doxorubicin combination enhances anticancer activity in breast cancer cells through Parkin-dependent mitophagy inhibition”的研究论...
导语:除抗氧化活性外,艾地苯醌对肺成纤维细胞的功能还具有抑制作用,前者主要是预防性的,而后者则对博来霉素诱导的纤维化具有治疗性。 来源:Medsci 背景在特发性肺纤维化(IPF)的发生和发展过程中,活性氧(ROS)所引起的肺泡上皮损伤和活...
这次学术大会是国际生物医药领域的一场科学盛宴,是面向高校、科研院所、医疗机构和生物医药企业创新发展需求,极具启发、引导作用的一次头脑风暴。本次大会还特别邀请了SpringerNature旗下的CellDeath&Disease杂志社主编赴会与参会人员交流,并作“HowtoGetPublished”专题报告,以满足科研人员论文发表的需要。 会议官网: http...
Although PARP-1 inhibitor olaparib increases DNA damage, ROS production, and cell death, it also blocks AMPK activation caused by UVA. Interestingly we found a dramatic nuclear export of AMPK upon UVA irradiation which is blocked by N-acetylcysteine and olaparib. In addition, UVA exposure ...
Ferroptosis is a form of cell death that has recently been reported during exposure to erastin, a chemical compound identified in a screen for molecules able to kill cancer cells carrying an active Ras oncogene. In cells exposed to inducers of ferroptosis, a catastrophic alteration of the cellular...
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ultimately resulting in the patient’s death. Research indicates that, on average, four out of every five DMD patients succumbs to heart failure or respiratory failure [124]. To investigate this disease, Ghori et al. extracted urinary stem cells (USCs) from Pakistani children and efficiently rep...
The liver is the largest immune organ of the human body. Because of acute or chronic infection, liver inflammation results in necrotic hepatocyte death [111]. Persistent hepatic damage leads to progressive fibrosis, disrupted liver architecture, cirrhosis, and subsequent tumorigenesis. The identification...
(Alves et al.,2016;Peetla et al.,2013). This may arise from the plasma membrane sealing, by the reduction of empty spaces in the lipid bilayer. Interestingly, mitochondrial membranes stiffness seems to be involved in the resistance of neoplastic cells to death signal and the stimulation of ...