Cell Death Discovery是一本多学科、国际、在线、开放获取的期刊,致力于发表医学与生物化学、药理学、免疫学、细胞生物学和细胞死亡交叉领域的研究,前提是它是科学合理的;该杂志不受限制地获取研究成果,将促进基础科学家和临床医生以及专注于癌症、神经生物学和炎症研究的行业研究人员之间进行充满活力和高效的交流。是细...
Known as a highly conserved programmed cell death, apoptosis is a rational and active decision made to sacrifice certain cells for the better benefits of the organism [132]. Apoptosis plays key roles in various cellular processes, including homeostasis, development, immunity cell survival and fate ...
Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell proliferation and induction of cell death. Many research publications discussing the mechanisms of anticancer drugs use the terms “cell death” and “apoptosis
Plaque is a common clinical manifestation of atherosclerosis, leading to reduced blood supply and increasing the risk of heart attack, stroke, and even death [96, 97]. Plaque regression is an important clinical objective for reducing the burden of cardiovascular disease. The single-cell analysis te...
Furthermore, it has been shown, in single cell assays, that Bmi-1−/− CD34− KSL HSCs, that is LT-HSCs, undergo the first cell division in a fashion similar to that of wt control and showed no detectable apoptotic cell death, although total Bmi-1−/− BM cells presented a ...
while syncytial knots form closer to the term and protrude slightly from the surface of the villi. An increased number of syncytial knots has been reported in the placenta of pregnancies with combined PE and FGR, whether this phenomenon reflects an exaggerated aging or apoptotic death of STB is...
7e), which is expressed in stretch cells starting at Stage 10 to induce nurse cell death66. In addition, this cluster also contains a subset of cells that express Sox14, which we found is expressed in late-stage follicles beginning in Stage 9 (Fig. 7i, t, Supplementary Fig. 7k). ...
An often-mentioned weakness in the innovation/commercialisation chain is the so-called ‘innovation chasm’ or the ‘valley of death’. This refers to the inability of academic research to reach the market as products and services. The National Biotechnology Strategy, which was adopted in 2001, ...
The low-affinity neurotrophin receptor, also known as p75NTR, transmits signals that lead to neuronal cell death [38]. A protein called the p75NTR-associated cell death executor (NADE) interacts with the structural domain of p75NTR located inside the cell [39]. Using the yeast two-hybrid me...
In conclusion, hESC research represents scientific innovation, ethical reflection, and regulatory prudence. As we continue to advance in this field, it is imperative to maintain a balanced approach that fosters scientific discovery while honoring ethical obligations and regulatory requirements. The future...