Cell-based assays in gpcr drug discovery. Biotechnol. J. 2008, 3, 471-483. [CrossRef] [PubMed]Siehler, S. (2008) Cell-based assays in GPCR drug discovery. Biotechnol. J. 3, 471-483.Siehler S. Cell-based assays in GPCR drug discovery. Biotechnol J 3: 471-483, 2008....
Reaction Biology provides cell based assay services for the screening of novel anti-cancer drugs. Learn more about our services today.
Reaction Biology provides cell based assay services for the screening of novel anti-cancer drugs. Learn more about our services today.
Indeed, several clinically promising cytotoxic and cytoprotective agents with potential applications in cancer, ischaemic and neurodegenerative diseases have recently been identified by high-throughput screening (HTS), based on appropriate cell death assays. Given that different cell death modalities may be ...
Dysregulated cell death occurs in many human diseases, and modulating the associated pathways has proved effective in the treatment of cancer, stroke and neurodegenerative disorders. In their review, Kepp and colleagues provide an overview of assays capa
Importance of the field: Screening compounds with a cell-based phenotypic approach complements target-based discovery programs because of the opportunity to investigate targets in the context of the cellular milieu and to discover novel targets. Areas covered in this review: Utilizing a cell-based apo...
Meanwhile, predicting cellular toxicity is important in the drug discovery process. Development of assay chemistries and signal detection technology both allow the cell-based assays miniaturized, which makes it convenient to perform dose-response experiments and other cell-based screening during primary ...
摘要: The use of cell-based assays is increasing in modern drug discovery programs because they provide a more biologically relevant context.Bioluminescence is uniquely suited for deve... 查看全部>>会议名称: 中国上海第七届国际新药发明科技年会 ...
Running assays in pharmacologically relevant cell types GeneBLAzer™ Reporter Gene AssaysThe GeneBLAzer technology utilizes a fluorescence resonance energy transfer (FRET)-based, ratiometric detection method that reduces experimental noise, which can lead to false hi...
Running assays in pharmacologically relevant cell types GeneBLAzer™ Reporter Gene AssaysThe GeneBLAzer technology utilizes a fluorescence resonance energy transfer (FRET)-based, ratiometric detection method that reduces experimental noise, w...