Siehler, S. Cell-based assays in gpcr drug discovery. Biotechnol. J. 2008, 3, 471-483. [CrossRef] [PubMed]Siehler, S. Cell-based assays in GPCR drug discovery. Biotechnol. J. 3, 471-483 (2008).Siehler S (2008) Cell-based assays in GPCR drug discovery. Biotechnol J 3:471–483...
Meanwhile, predicting cellular toxicity is important in the drug discovery process. Development of assay chemistries and signal detection technology both allow the cell-based assays miniaturized, which makes it convenient to perform dose-response experiments and other cell-based screening during primary ...
Indeed, several clinically promising cytotoxic and cytoprotective agents with potential applications in cancer, ischaemic and neurodegenerative diseases have recently been identified by high-throughput screening (HTS), based on appropriate cell death assays. Given that different cell death modalities may be ...
作者: F Fan 展开 摘要: The use of cell-based assays is increasing in modern drug discovery programs because they provide a more biologically relevant context.Bioluminescence is uniquely suited for deve... 查看全部>> 展开 会议名称: 中国上海第七届国际新药发明科技年会 会议时间: 2009-10-22 ...
Cell-Based Assays High-content cell imaging Cell viability, cytotoxicity & signaling 2D & 3D angiogenesis in 384-well plates 96-well tumor spheroids for drug testing 96-well TEER & transport testing in barrier tissues Multi-color FACS analysis ...
(DNA) technology have also enabled the ready use of human protein targets expressed in almost any cell. The culmination of this work, for drug discovery, has been the increased use ofwhole cellsin screening assays in search of effective therapeutic compounds. A cell-based assay for our ...
Running assays in pharmacologically relevant cell types GeneBLAzer™ Reporter Gene AssaysThe GeneBLAzer technology utilizes a fluorescence resonance energy transfer (FRET)-based, ratiometric detection method that reduces experimental noise, wh...
Running assays in pharmacologically relevant cell types GeneBLAzer™ Reporter Gene AssaysThe GeneBLAzer technology utilizes a fluorescence resonance energy transfer (FRET)-based, ratiometric detection method that reduces experimental noise, which can lead to false hi...
Dysregulated cell death occurs in many human diseases, and modulating the associated pathways has proved effective in the treatment of cancer, stroke and neurodegenerative disorders. In their review, Kepp and colleagues provide an overview of assays capa
drug discovery & development and the increasing preference for cell-based assays in drug discovery, government support and funding for cell-based research, and growing efforts by the FDA to curtail animal-based studies. The rising prevalence of cancer also drives the growth of the cell-based ...