贺智敏,魏立勇,彭祥鄂.ASSAY OF SENSITIVITY OF CANCER CELL TO ANTICANCER DRUG IN GLASS CAPILLARIES. Chinese Journal of Cancer Research . 1992He ZM, Wei LY, Peng X. Assay of sensitivity of cancer cell to anticancer drug in glass capillaries. Chin J Cancer Res. 1992; 4 :40–45.He Z M, ...
加州大学洛杉矶分校的Alice Soragni教授团队在《Cell Stem Cell》(IF:19.8)上发表了“The landscape of drug sensitivity and resistance in sarcoma”;本研究利用患者来源的肿瘤类器官 (PDTO) 来研究肉瘤的药物敏感性和耐药性,并探索其在精准医疗中的应用。研究人员从 126 名患者身上收集了 194 份样本,涵盖了 24...
To help address these issues and stimulate debate, here we propose a set of principles to facilitate the definition and development of disease-relevant assays, and we discuss new opportunities for exploiting the latest advances in cell-based assay technologies in drug discovery, including induced ...
The development of reliable, accessible, and scalable viability assays based on cell death–associated effects of biomarkers is extremely important for efficient screening of drug toxicity. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay is currently one of the ...
This assay is an important development for the rapid and quantitative screening of agents that affect cell proliferation. The CyQUANT assay is based on the use of our green-fluorescent CyQUANT GR dye, which exhibits strong flu...
5,6,13 In addition, the required assay sensitivity to predict the success of an AAV-mediated gene therapy remains to be elucidated. In this study, we maximized the sensitivity of cell-based Nab assays and found the appropriate vector genome for the detection of marginal Nabs. Furthermore, we...
First, we studied the origins of the large inter-center variability in estimation ofGRmaxfor the topoisomerase inhibitor Etoposide and CDK4/6 inhibitor Palbociclib. We ascertained that one center had used the CellTiter-Glo ATP-based assay and a luminescence plate reader as a proxy for counting th...
This study utilized the cell counting kit-8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU), and colony formation assay to evaluate the effect of S109 combined with radiotherapy on the proliferation and survival of GBM cells. The therapeutic efficacy of S109 combined with radiotherapy was evaluated...
We describe the development, optimisation, and validation of an automated, cell-based and high-throughput screening assay using existing luminescence-based ATPlite reagents for identifying antiviral compounds that inhibit enterovirus replication. Antiviral efficacy was determined by measuring the ATP levels in...
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma Fan Yang ,Tian Xia &Chunxia Liu Article 29 November 2024|Open Access Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4/FTH1-mediated...