SPR‐based direct binding assays ‐ in drug discoveryscreening using SPR‐based direct binding assay ‐ pharmaceutical industry, exploring new and innovative methods, discovering small molecule drug candidateshigh quality hit and lead compound identification ‐ in discovery of new drug molecules...
Nature Reviews Drug Discovery volume 10, pages 221–237 (2011)Cite this article 27k Accesses 433 Citations 10 Altmetric Metrics details Key Points In response to cytotoxic insults, cells die by different subroutines that are mainly based on apoptosis and necrosis and often preceded by a global ...
Viral-mediated gene delivery for cell-based assays in drug discovery. Expert Opin Drug Dis 4: 243-256 : We compare and contrast the current viral-mediated gene delivery vector systems and highlight their suitability for cell-based drug discovery assays. ... RS Ames,Q Lu - 《Expert Opinion ...
Conventional drug sensitivity assays used to screen prospective anti-cancer agents for cytotoxicity monitor biological processes associated with active growth and proliferation, used as proxies of cell viability. However, these assays are unable to disti
Alzheimer's disease (AD) is a debilitating mental disorder involving severe cognitive impairment. Over 10 million people are afflicted with AD, resulting in hea...
Integrated Kinase Discovery Services Kinase Assays Services Kinase Panel Screening Cellular Kinase Assays BaF3 Cell Proliferation Assay Cellular Phosphorylation Assay NanoBRET TE Intracellular Kinase Assay EGFR Drug Discovery Kinase SubstrateFinder KinaseFinder Customized Kinase Drug Discovery In Vivo Kinase Act...
Cell death assays for drug discovery 来自 掌桥科研 喜欢 0 阅读量: 124 作者: O Kepp,L Galluzzi,M Lipinski,J Yuan,G Kroemer 展开 摘要: Cell death has an important role in many human diseases, and strategies aimed at modulating the associated pathways have been successfully applied to ...
2006. Chapter 10: Protein kinase assays for drug discovery. Glycogen Synthase Kinase-3 (GSK-3) and its Inhibitors-Drug discovery and Development. B. Wang (Ed.). Wiley Series in Drug Discovery and Development, pp.189.
Drug Discovery and Evaluation Pharmacological Assays Vogel, Hans G. (Ed.) Version: eReference (online access) 3rd completely rev. and enlarged ed., 2008, eReference ISBN: 978-3-540-70995-4 About this book * Updated to include the latest methods in molecular biology and genetic engineering ...
Practical Applications of XY-69 in Drug Discovery ScreeningTheir research led to the development of a high-throughput assay capable of capturing both orthosteric and allosteric inhibitors. The newly developed assay focused on PLC-γ isozymes, which have several regulatory domains unlike other PLC subfa...