drug developmentIntroduction: Cystic Fibrosis (CF) is the most common fatal genetic disease in persons of Northern European ancestry. It is an autosomal recessive disease caused by loss of function of the cystic fibrosis transmembrane conductance regulator protein (CFTR), a transmembrane chloride and ...
Development of ligand-binding assays for drug development support. In: Khan MN, Findlay JW, editors. Ligand-binding assays: development, validation, and implementation in the drug development Arena. Hoboken: Wiley; 2009. p. 39–79.KAHN, M. N.; DASS, P. D.; LEETE, J. H.; SHUMAN R. ...
Practical Applications of XY-69 in Drug Discovery Screening Their research led to the development of a high-throughput assay capable of capturing both orthosteric and allosteric inhibitors. The newly developed assay focused on PLC-γ isozymes, which have several regulatory domains unlike other PLC sub...
Ligand- Binding Assays: Development, Validation, and Implementation in the Drug Development Arena. John Wiley & Sons. p. 324Khan MN, Findlay JW. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena. Fit-For-Purpose Method Development and Va...
This article discusses some of the in vitro and in vivo assays employed by researchers during the drug discovery and developability assessment phases of the discovery and development processes.Keywords:in vivo assays;in vitro assays;drug discovery;drug development 展开 关键词: discovery lead ...
In vitro tools, including assays using human primary immune cells Immunogenicity assessment Immuno-oncology focused functional assays, such as T-cell killing and exhaustion assays or myeloid cell assays Potency assays (functional screening and potency assays, cellular disease models, drug MoA)...
Development and Validation of a Quantitative Gas Chromatography – Mass Spectrometry Confirmatory Method for Phenylbutazone in Equine Plasma The non-steroidal anti-inflammatory drug phenylbutazone is known to have a number of adverse side effects, however, its use in the equine remains widesprea......
In Vitro ADME Assays In Vitro ADME assay is an essential step in drug development. We will help you to understand the Adsorption, Distribution, Metabolism, Excretion (ADME) as well as the Pharmacokinetics (PK) of your compounds, which will help both your
Poster VideoIC Assay for Lithium in Lithium CitrateAssay, impurityIonPac CS12A Application BriefIC Assay for Lithium, Sodium, and Calcium in Lithium CarbonateAssay, impurityIonPac CS16AB71919 WebinarIC Assay Methods for Impurities, Degradation P...
Epigenetic Targets in Drug Discovery: Cell〣ased Assays for HDAC Inhibitor Hit Validation 来自 Wiley 喜欢 0 阅读量: 13 作者:M Jung,KJ Yong,A Velena,S Lee 摘要: IntroductionIn Vitro Assays for HDAC InhibitorsCell-Based AssaysBiological Function-Based AssaysHDAC Isoform Functional AssaysAnticancer ...