Cancer Chemotherapy and PharmacologyOzawa S, Sugiyama Y, Mitsuhashi Y, Kobayashi T, and Inaba M (1988). Cell killing action of cell cycle phase - non-specific antitumor agents is dependent on concentration - time product. Cancer Chemo- ther Pharmacol 21, 185 - 190....
As detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human cancers may impair the ability of the cells to respond to ...
Aberrant activity of cell cycle protein kinases, leading to uncontrolled cell proliferation, is a hallmark of human cancer. Here, Lapenna and Giordano review recent progress in the modulation of specific protein kinase activity for the treatment of vario
Therefore, cell cycle regulators are considered attractive targets in cancer therapy. Intriguingly, animal models demonstrate that some of these proteins are not essential for proliferation of non-transformed cells and development of most tissues. By contrast, many cancers are uniquely dependent on these...
Cell-Cycle Regulation Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy (Second Edition) Book2018, Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy (Second Edition) Sheila Figel, Robert A. Fenstermaker Explore book Conclusion The cell cycle is ne...
On the basis of knowledge about the cell cycle and gene expression regulation, the first therapeutic proteins were produced using mammalian cell cultures. The end of twentieth century and early twenty‐first century brought the progress in 3‐D cell culture technology and created the possibility of...
Recombinant PH20 protein has been shown to enhance the penetration of chemotherapy drugs and the infiltration of immune cells [99]. Zhao et al. discovered that co-expression of secreted PH20 significantly enhanced the degradation capacity of anti-MSLN CAR-T cells towards HA, leading to improved ...
In general, the IC50 values of all the materials, expressed as a function of the functionalized metal quantity, shows a higher cytotoxic activity than carboplatin (in some cases even up to 50 times higher), indicating the promising potential of the systems in anticancer chemotherapy. However, ...
C. The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies. Nat. Immunol. 21, 835–847 (2020). Article CAS PubMed PubMed Central Google Scholar Liu, S. et al. NK cell-based cancer immunotherapy: from basic biology to clinical development. J. Hematol. ...
Table 3. Therapies with immune checkpoint inhibitor (ICI) pathways in non-clear cell renal cell carcinoma (nccRCC). 2.4. Chemotherapy Cytotoxic chemotherapy is the mainstay of medical treatment in collecting duct carcinoma and renal medullary carcinoma, which are generally resistant to other systemic...