In this study, we used hollow mesoporous manganese dioxide (HMnO2), which has a high specific surface area and good tumor microenvironment responsiveness, as a carrier. It was modified using poly (allylamine hydrochloride) (PAH) to exploit its cationic properties for reversing the charge of mangan...
Changes in ES cell number could be due to a function of the respective gene in cell-cycle progression, cell survival, or prevention of lineage-specific differentiation. Downstream effects of changes of gene expression were determined with DNA microarrays. Such an approach also applies to the study...
apoptosis in MCF-7 and MDA-MB-231 cell lines, as shown by Flow Cytometry analysis; ***p < 0.001 in comparison with control group using independent sample T-test; B: Meanwhile, MCF-7 and MDA-MB-231 cells subjected to apoptotic analysis were in parallel subjected to cell cycle ...
infiltration, metastases, and therapy response, have been linked to specific patterns of DNA methylation (DNAm) [77,78]. Studies have shown that hyper and hypo-DNAm by DNMTs (DNA Methyltransferases) result in transcriptional silence of tumor-suppressive genes and transcriptional activation of proto-...
[90]. M-MDSCs and PMN-MDSCs were reported to exert different mechanisms of immune suppressions. M-MDSCs can suppress both antigen-specific and nonspecific T cell responses and show stronger suppressive activities than PMN-MDSCs. M-MDSCs exert immunosuppression through production of NO, however,...
4C). For transcriptional regulatory analysis of PACSI-identified cells, SOX4, JUND, TWIST1, and FOS were identified as the most specific regulators (Fig. 4D and Additional file 3). Moreover, SOX4 can promote the growth and metastasis of breast carcinoma and has been proposed as a biomarker...
Cell identity is maintained by activation of cell-specific gene programs, regulated by epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4)-folded regions in cells were reported to be associated with either increased
Future studies could examine CLA-specific inhibition with Nurr1 ablation in parallel and assess the same behaviors that have been described to be affected by CLA inhibition. Several of the studies that address the behavioral readouts of CLA inhibition employ transgenic mice that provide precise ...
Renal cell carcinoma (RCC) is not sensitive to conventional radio- and chemotherapies and is at least partially resistant to impairments in cell death-related signaling pathways. The hallmarks of RCC formation include diverse signaling pathways, such as
mitochondria harboring mutant mtDNA is also selectively enriched in large EVs such as migrasomes, a process known as mitocytosis [64]. These studies underscore the selective and cell-dependent packaging of DNA into distinct EV subtypes, which may be also dependent on the specific cellular origin [...