【答案】：细胞周期非特异性药物：是指能够杀灭处于增殖周期各时相的细胞甚至G0期细胞的抗恶性肿瘤药。如烷化剂、抗肿瘤抗生素和铂类抗肿瘤药物。
Epigenetic gene regulation in the heterogeneous brain remains challenging to decipher with current strategies. Bulk tissue analysis from pooled subjects reflects the average of cell-type specific changes across cell-types and individuals, which obscures
We next evaluated the specific fractions of treated cells using flow cytometry with Annexin V/PI staining. It confirmed that cisplatin treatment induced apoptosis in SW620 cells and revealed that the majority of cisplatin-treated cells were in the state of early apoptosis (Fig. 2c, Supplementary ...
apoptosis in MCF-7 and MDA-MB-231 cell lines, as shown by Flow Cytometry analysis; ***p < 0.001 in comparison with control group using independent sample T-test; B: Meanwhile, MCF-7 and MDA-MB-231 cells subjected to apoptotic analysis were in parallel subjected to cell cycle ...
Most important, through progress in these fields it has been discovered that precursor cells residing in discrete regions of the adult brain are able to generate specific sub-classes of neurons throughout life under physiological conditions, but have also the initial intrinsic potential to contribute ...
This model refers to the phenotypical changes that occur in stem cells during the cell cycle [18]. The continuum model is based on the assumption that periodical and fluctuating phenotypical changes in stem cells cause the inevitable heterogeneity of their population, which – in turn, is ...
which influences cytoskeleton reorganization. Moreover, knockdown of ERp57 in BO2 cells confirmed its bone organ-specific prometastatic role. Altogether, ERp57 appears as a multifunctional chaperone that can regulate diverse biological processes to maintain the homeostasis of breast cancer cells and promote...
Subcluster-specific transcriptional changes in FL stroma We next performed multistep DEG analyses in NHC subclusters of MFLNs and FL by monitoring differences in gene expression between mesenteric LNs (mLNs) and peripheral LNs (pLNs) (Extended Data Fig.6a,b, Supplementary Tables13and14andSupplemen...
Small-cell carcinoma of the ovary of hypercalcemic type (SCCOHT) and endometrial cancer from type 1 and type 2 are gynecological tumors that affect women worldwide. The treatment encompasses the use of cytotoxic drugs that are nonspecific and inefficient. “Mitocans”, a family of drugs that ...
Within each cycle, 11 cell positions were scanned, capturing 60 frames per position. The video setting was on “high,” with the following specific settings: focus set to autofocus, camera sensitivity at 92.0, shutter speed at 70, scattering intensity at 4.0, and a cell temperature of 23 °...