This chapter describes the cell cycle, DNA replication, and repair. The cell cycle is the period during which the cell duplicates its entire contents such that on subsequent cell division, each daughter cell contains all the material originally present in the parent cell at the beginning of its...
生物通报道:来自北京大学生命科学学院,加拿大西奈山医院等处的研究人员发表了题为“A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice”的文章,DNA双键断裂修复机制中的一个关键环节:发现了53BP1的下游效应蛋白Rif1,由此找到了由RIF1和BRCA1主导...
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights str...
Cell cycle regulation of DNA repair in normal and repair deficient human cells. Chem Biol Interact. 1981 Jul; 36 (1):19–31.Gupta, P. K., and Sirover, M. A., 1981, Cell cycle regulation of DNA repair in normal and repair deficient human cells, Chem. Biol. Interact . 36 : 19–...
Cell cycle, DNA repair, normal human fibroblasts, nonhomologous end joining, homologous recombinationDNA double-strand breaks (DSBs) are dangerous lesions that can lead to potentially oncogenic genomic rearrangements or cell death. The two major pathways for repair of DSBs are nonhomologous end ...
Fig. 3: Combining DNA repair modulation and cell-cycle synchronization synergistically enhances HDR in iPS cells. aList of compounds tested with their function on molecular targets (top), and experimental timeline of compound pre- (4 h) and post-EP (48 h) treatment (bottom).bScreening of...
It has been established in yeast that the response to ionizing radiation is cell-cycle dependent. These observations can be interpreted in terms of variations in the ability to repair DNA double-strand breaks (DSB). In the present work, DSB repair was examined directly in synchronous yeast cultu...
Cell Cycle/DNA Damage——RAD51(10) Cat. No.Product NameCAS No.PurityChemical Structure KM2412Amuvatinib Amuvatinib (MP470) 是一种多靶点酪氨酸激酶抑制剂,对突变c-Kit,PDGFRα,Flt3,c-Met和c-Ret具有有效活性。Amuvatinib (MP470) 还是一种 DNA 修复抑制剂,靶向蛋白 DNA 修复RAD51,从而破坏 ...
Here we report the concentration-dependent effects of BDM on cell cycle, DNA damage, checkpoint response and cell death in HeLa cells. Low concentrations of BDM transiently arrested cells in G2, while a 4-fold higher concentration arrested cells in S phase. DNA damage at 50, but not 200 ...
Together these studies highlight the importance of cell cycle and cell type specific modulation of the Mre11 complexs repair activities in vivo. 展开 关键词: Mre11 Rad50 Nbs1 DSB repair postmitotic meiosis cell cycle telomere DOI: 10.4161/cc.8.10.8380 被引量: 14 ...