真核细胞中,DNA缠绕在组蛋白(histone)上(下图左图的蓝色结构),形成核小体(nucleosome),核小体进一步形成染色质(chromatin),染色质呈细丝状。 S phase发生DNA复制( DNA replication),复制后的DNA并没有立刻分开,而是通过着丝粒(centromere)连在一起,两条DNA被称为姐妹染色单体(sister chromatid)。此时的chromatin数目...
(1992). DNA replication and the cell cycle. Ciba Found Symp 170:147-56; discussion, 147- 56; discussion 156-6.Stillman B, Bell SP, Dutta A, Marahrens Y. DNA replication and the cell cycle. Ciba Found Symp 1992;170:147-156. discussion 156-160. [PubMed: 1336449]...
一对chromosome里面两个chromatid相同(结构相同,功能相同) cell division主要由两个大步构成:interphase 和mitosis/meiosis •Interphase -- G1, S, G2 --in G1, cell grows to normal size (normal functions are carried out. Protein synthesis) --in S, DNA replication ∴each chromosome is made of tw...
This collection showcases ground-breaking cell cycle papers and reviews, ranging from basic discoveries to clinical applications.
相关知识点: 试题来源: 解析 A。细胞周期中,间期负责 DNA 复制。间期包括 G1 期、S 期和 G2 期,其中 S 期进行 DNA 复制。前期(B 选项)主要是染色体出现等变化。中期(C 选项)染色体排列在赤道板上。后期(D 选项)姐妹染色单体分离。反馈 收藏
而在受精之后,合子染色质重构的首要任务便是对精子携带入卵细胞的父源基因组进行快速、高效的解压缩,即用母源组蛋白替换包裹精子DNA的鱼精蛋白(“鱼精蛋白- 组蛋白置换”)。过去已有的研究表明,一类在卵细胞中高度表达的酸性蛋白因子nucleoplasmin(NPM2)在这一过程中参与将鱼精蛋白由父源染色质中移除【1-6】;...
DNA Replication and the Cell Cycle 来自 Semantic Scholar 喜欢 0 阅读量: 45 作者: JA Bryant 摘要: The replication of the genetic material, DNA, and its subsequent distribution to two daughter cells are perhaps the most fundamental processes carried out by living organisms, ensuring that each ...
Cell Cycle Regulation of DNA ReplicationManuscript, AuthorSclafani RA, Holzen TM 2007 Cell cycle regulation of DNA replication. Ann Rev Genet 41:237-280RA Sclafani and TM Holzen. Cell cycle regulation of dna replication. Annu Rev Genet, 41:237-280, 2007.Sclafani,R.A. and Holzen,T.M. (...
The Translational Landscape of the Mammalian Cell Cycle Gene regulation during cell-cycle progression is an intricately choreographed process, ensuring accurate DNA replication and division. However, the translational landscape of gene expression underlying cell-cycle progression remains largely unknown. Employi...
Cell cycle expression of origin-licensing factors and tumour cell kinetics Determination of the molecular and temporal events comprising the process of mammalian DNA replication often requires the use of synchronous cell populations. We have examined expression of the standard proliferation marker Ki67, th...