The exact execution of DNA replication depends on a large number of proteins that are being studied extensively in the cell cycle field. Some of these proteins, such as the minichromosome maintenance proteins (MCMs), are essential for the process of DNA replication itself. Others such as ...
(2007) Cell cycle regulation of DNA replication. Annu. Rev. Genet., 41, 237-280.Sclafani, R.A. and Holzen, T.M. (2007). Cell cycle regulation of DNA replication. Annu Rev Genet 41, 237-280.Sclafani RA, Holzen TM. Cell cycle regulation of DNA replication. Annu Rev Genet. 2007;41...
A. Interphase B. Prophase C. Metaphase D. Anaphase 相关知识点: 试题来源: 解析 A。细胞周期中,间期负责 DNA 复制。间期包括 G1 期、S 期和 G2 期,其中 S 期进行 DNA 复制。前期(B 选项)主要是染色体出现等变化。中期(C 选项)染色体排列在赤道板上。后期(D 选项)姐妹染色单体分离。
The replication of DNA in the eukaryotic cell cycle is one of the most highly regulated events in cell growth and division. Biochemical studies on the replication of the genome of the small DNA virus simian virus 40 (SV40) have resulted in the identification of a number of DNA replication pr...
Thecell cycleis an ordered series of events involving cell growth and cell division that produces two new daughter cells. Cells on the path to cell division proceed through a series of precisely timed and carefully regulated stages of growth, DNA replication, and division that produces two identic...
the G2checkpoint is to ensure that all of the chromosomes have been replicated and that the replicated DNA is not damaged. If the checkpoint mechanisms detect problems with the DNA, the cell cycle is halted, and the cell attempts to either complete DNA replication or repair the damaged DNA....
in response totelomereshortening, DNA damage, and oncogenic signaling. In cellular senescence, growth arrest occurs in G1 and possiblyG2 phaseof the cell cycle. During cell growth arrest, the nutrient-sensing pathways like mTOR (mechanistic target of Rapamycin) continue to be active withoutcell ...
DNA Replication DNA and certain proteins known as histones form the chromosomal structures. The DNA is double-stranded and forms a tightly coiled package with the assistance of the histones. During interphase, the chromosomes relax, giving replication enzymes access to create a new copy of each chr...
When DNA double-strand breaks (DSB) are induced by ionizing radiation (IR) in cells, histone H2AX is quickly phosphorylated into γ-H2AX (p-S139) around the DSB site. The necessity of DNA-PKcs in regulating the phosphorylation of H2AX in response to DNA damage and cell cycle progression was...
The convergence point of growth-signalling pathways that control cell proliferation is the initiation of genome replication, the core of which is the assembly of pre-replicative complexes (pre-RCs), resulting in chromatin being ‘licensed’ for DNA repli