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The initiation of chromosomal replication is tightly coupled to removal of the license and thus prevention of re-licensing following origin firing. This step is critical as replication must occur once, and only once, per cell cycle to ensure genomic stability. As such, human cells have adopted ...
2. Hartwell, L. H. & Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events.Science246, 629–634 (1989).3. Magiera, M. M., Gueydon, E. & Schwob, E. DNA replication and spindle checkpoints cooperate during S phase to delay mitosis and preserve genome in...
The replication of the genetic material, DNA, and its subsequent distribution to two daughter cells are perhaps the most fundamental processes carried out by living organisms, ensuring that each cell generation contains the same set of information as the previous cell generation. At the most basic ...
Cell cycle checkpoints , genetic stability and DNA 损伤引起的细胞周期检定点阻滞的适应 , cancer. Seminar Cancer Biol. 1993 , 4 (2) : 129～140 CDC5 编码一个完成分裂后期所必需的激酶 , 它属 5 Anderson C W. Protein kinases and the response to DNA damage. Seminar Cell Biol , 1994 , 5 ...
[16] Lodovichi, S.et al. Effect of BRCA1 missense variants on gene reversion in DNA double-strand break repair mutants and cell cycle-arrested cells of Saccharomyces cerevisiae [J]. Mutagenesis 35, 189–195 (2020). [17] Roth, D. B. & Wilson, J. H. Relative rates of homologous and...
近日,来自美国加州大学旧金山分校的Jeremy F. Reite与Semil P. Choksi共同在Nature期刊发表题为An alternative cell cycle coordinates multiciliated cell differentiation(一种细胞周期协调的多纤毛细胞分化) 的文章。研究发现多纤毛细胞采用一种新的细胞周期,称为多纤毛细胞周期,来调控其分化过程。这种细胞周期能够调整经...
THE CELL CYCLE DEPENDENT AND THE DNA-DAMAGING AGENT-INDUCED CHANGES OF CELLULAR NAD CONTENT AND THEIR SIGNIFICANCE .THE CELL CYCLE DEPENDENT AND THE DNA-DAMAGING AGENT-INDUCED CHANGES OF CELLULAR NAD CONTENT AND THEIR SIGNIFICANCE.[J];Acta Biologiae Experimentalis Sinica... YF Dai,YN Yu,XR Chen...
Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christmann, et al. Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and ...