Umeda教授说:“总的来说,DNA没有损伤的情况下,CDK有效阻止了Rep-MYB,让细胞得以进入分裂。DNA损伤后,CDK活性受到抑制,不受约束的Rep-MYB就会阻断细胞分裂。” 原文标题:Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage. Nature Communications. 8:635, 21 ...
DNA damage triggers surveillance mechanisms, the DNA checkpoints, that control the genome integrity. The DNA checkpoints induce several responses, either cellular or transcriptional, that favor DNA repair. In particular, activation of the DNA checkpoints inhibits cell cycle progression in all phases,...
MCE 细胞周期-DNA 损伤化合物库 Cell Cycle-DNA Damage Compound Library.docx,信号通路化合物库系列 According to Signaling Pathway or Protein Family 细胞转导是一个复杂的网络系统,包括细胞-细胞间的相互作用及细胞内的信号转导。胞外信号分子经受体介导进入胞内的信
5.Jackson AL, Loeb LA. 2001. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 477(1-2):7-21.6.De Bont R. 2004. Endogenous DNA damage in humans: a review of quantitative data. Mu...
DNA Damage, Repair, and Cancer Metabolism. Front Oncol. 2018 Feb 5;8:15. Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christmann, et al. Transcriptional ...
Cell cycle checkpoints , genetic stability and DNA 损伤引起的细胞周期检定点阻滞的适应 , cancer. Seminar Cancer Biol. 1993 , 4 (2) : 129～140 CDC5 编码一个完成分裂后期所必需的激酶 , 它属 5 Anderson C W. Protein kinases and the response to DNA damage. Seminar Cell Biol , 1994 , 5 ...
MCE 国际站:Cell Cycle/DNA Damage Compound Library作用靶点:Compound Library产品活性:DNA 容易受到多种形式的损伤,为了应对 DNA 损伤,细胞已经进化出一系列的修复机制。不断生长和增殖的细胞受到到 DNA 损伤的几率会更高。细胞周期检查点代表DNA 修复的整体组成部分,通过协调细胞周期及其他生化途径,以应对损伤,恢复...
DNA damage response (DDR) ——损伤太强导致的细胞周期停滞(cell-cycle arrest) DNA分子在进行一系列DNA的复制、包装、分离和转录等复杂的动态过程中伴随着大量的DNA损伤及复制错误。基因组还会受到各种存在于环境中的诱变剂攻击,例如电离辐射和化学试剂。各式各样的基因毒性压力伴随着许多类型的基因突变,包括双螺旋...
3. Maynard, S., Schurman, S.H., Harboe, C., de Souza-Pinto, N.C. and Bohr,V.A. (2009) Base excision repair of oxidative DNA damage and association with cancer and aging.Carcinogenesis, 30, 2–10. 4. Beard, W.A., Hor...
5.Jackson AL, Loeb LA. 2001. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 477(1-2):7-21.https://doi.org/10.1016/s0027-5107(01)00091-4 ...