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This chapter describes the cell cycle, DNA replication, and repair. The cell cycle is the period during which the cell duplicates its entire contents such that on subsequent cell division, each daughter cell contains all the material originally present in the parent cell at the beginning of its...
The transcriptional and translational control elements identified are conserved in mammalian cells, underscoring the use of yeast as a model system to examine the regulation of MSH2. (C) 2012 Elsevier B.V. All rights reserved. 展开 关键词: Mismatch repair Cell-cycle DNA damage Transcription ...
Abstract 1315: CtIP is regulated by the APC/C-Cdh1 to mediate cell cycle-dependent control of DNA repair Human cells have evolved elaborate mechanisms for responding to DNA damage to maintain genome stability and prevent carcinogenesis. For instance, the cell ... HRD Boer,L Lafranchi,C Neugebau...
TLSs in MIBC are distinguished by the presence of a central region of CD19+ B cells forming a follicular structure characteristic of a germinal center and surrounded by T cells. Interferon-stimulated B-cell subtype and tertiary lymphoid structures are associated with favorable survival in MIBC pati...
Despite the importance of cardiomyocyte proliferation in cardiac development and regeneration, the mechanisms that promote cardiomyocyte cell cycle remain incompletely understood. RE1 silencing transcription factor (REST) is a transcriptional repressor o
Whole-genome sequencing, or WGS, is performed to sequence the entire genome of an organism using the total genomic DNA. WGS data of a sample is then compared to a reference sample or control—for instance, comparison between c...
aUpon DNA damage, cells rapidly initiate the DDR signaling network by coordinating multiple cellular processes, including cell cycle checkpoint control, and DNA repair and apoptosis, to maintain genomic integrity and prevent tumorigenesis. 在脱氧核糖核酸损伤,细胞通过协调多个多孔的过程,包括细胞周期检查站控...
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