During the inflammatory responses, leukocytes are recruited at the site of high endothelial venule, roll over the endothelium surface, form the firm adhesion to spread out, and finally transmigrate across the blood vessel to the inflammatory site. Similar cascade is also found in tumor metastasis ...
Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Integrins are essential for the development of the two genetically tractable invertebrate model organisms, the nematode worm Caenorhabditis elegans and the... NH Brown - 《Matrix Biology》 被引量: 185发表: 2000年 Cell–matrix ...
According to the present invention it was found that the urokinase receptor induces the 尾-integrin-mediated activation of leukocytes and tumor cells, leading to an adhesion of these cells to endothelial cells, a pathway which plays an important role in hyperinflammatory conditions and the formation...
aCell adhesion molecules integrin αV can influence the radiosensitivity of human nasopharyngeal carcinoma CNE-2Z cells and the inhibition of cell apoptosis might be its mechanism, proved by three dimensional culture model to mimic solid tumor in vivo. 细胞粘着分子integrin αV可能影响人的鼻咽癌CNE-2Z...
Figure 1.Different forms of cell–cell adhesions. Illustration depicting several possible modes of interaction between similar or different cells, mediated via similar or different adhesion receptors. The aim of this article is to provide molecular insights into the mechanisms by which the structural an...
Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis Michael J. V. White ,Melis Ozkan &Jeffrey A. Hubbell Article 30 August 2024|Open Access Talin2 binds to non-muscle myosin IIa and regulates cell attachmen...
Pacific oyster hemocytes undergo apoptosis following cell-adhesion mediated by integrin-like molecules Previously, we demonstrated that in the Pacific oyster ( Crassostrea gigas, a bivalve mollusc) apoptosis could be induced in hemocytes by treatment with Ar... K Terahara,KG Takahashi,K Mori - 《...
Integrin-mediated adhesion is regulated by multiple features of the adhesive surface, including its chemical composition, topography, and physical properties. In this study we investigated integrin lateral clustering, as a mechanism to control integrin functions, by characterizing the effect of nanoscale ...
在曼彻斯特大学Martin Humphries教授的领导下,Dr Mark Morgan及其同事针对整合素integrin进行了研究。这些分子是机体内细胞迁移的关键,它们会像手一样抓住细胞周围的纤维,拖动细胞。不过细胞表面上的整合素有多种类型,它们的特性影响着细胞移动的快慢。 细胞会将使用过的整合素从细胞表面移除,把它们转移到细胞内的仓库中。
Integrin cell adhesion is mediated by proteins generated by epithelial cells in the extracellular matrix known as thebasal lamina. Integrins use adaptor proteins like plectins and BP230 to attach the extracellular matrix to keratin intermediate filaments. ...