因此,全面了解CD8 T细胞的异质性和发育将对各种人类疾病和治疗产生重大影响,包括针对感染性疾病的疫苗开发、针对自身免疫的免疫抑制剂和针对癌症的检查点阻断。 参考文献:Muroyama Y, Wherry EJ. Memory T-Cell Heterogeneity and Terminology. Cold Spring Harb Perspect B...
Malonate promotes CD8+T cell memory formation via protein malonylation Qianqian Duan Jiajia Wang Lianjun Zhang Research14 May 2025Cellular & Molecular Immunology Volume: 22, P: 674-689 T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
We observed an increase in the number of T cells (but not B cells) and monocytes selectively infiltrating into AD relative to control cultures. Infiltration of CD8+ T cells into AD cultures led to increased microglial activation, neuroinflammation and neurodegeneration. Using single-cell RNA-...
T cells. Activated CD8+ T cells treated ex vivo with simultaneous inhibition of A2AR and lipid peroxidation acquire a superior capacity to proliferate and persist in vivo, demonstrating a translatable means to prevent ferroptosis in adoptive cell therapy. Additionally, we identify a particular cluster...
induced by NaCl. Thus, NaCl metabolism is a regulator of CD8+ T cell effector function, with potential implications for cancer immunotherapy. CD8+ T细胞可控制肿瘤,但在肿瘤微环境中不可避免地会功能失调。在此,我们证明氯化钠(NaCl)可抵消T细胞功能障碍,促进癌症消退。在CD8+ T细胞培养期间补充氯化钠可...
近日，来自美国宾夕法尼亚大学的E. John Wherry带领团队在Science Immunology杂志以 In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40 发表了他们最新的研究成果，他们建立一种体外T细胞模型，能够很好的模拟慢性感染或者癌症引起的T细胞耗竭生物学功能，他们将这种...
2023年10月20日,董晨院士团队在Science Immunology期刊发表了题为:BCL6 promotes a stem-like CD8+T cell program in cancer via antagonizing BLIMP1的研究论文。该研究详细阐述了TGF-β-BCL6和IL-2-BLIMP1信号通路拮抗调控抗肿瘤CD8+T细胞分化的重要作用和分子机制。
3. A. B. Morris, C. R. Farley, D. F. Pinelli, L. E. Adams, M. S. Cragg, J. M. Boss, C. D. Scharer, M. Fribourg, P. Cravedi, P. S. Heeger, Signaling through the inhibitory Fc receptor FcγRIIB induces CD8+ T cell apoptosis to limit T cell immunity. Immunity 52, ...
IPHASE Human CD8+ T Cell Isolation Kit 阳性分选 【试验原理】 免疫磁性细胞分选是用磁珠抗体偶联系统从样本细胞悬液中选择性吸附靶细胞的方法。其借助偶联于磁性微粒上抗体的高度特异性,识别并标记靶细胞的表面抗原,再通过外加磁场的作用,使结合了磁珠的靶细胞被吸附于磁场中,而未结合的细胞被除去,得到纯化的靶...