近日，来自Vanderbilt-Ingram癌症中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger合作在Nature Reviews Immunology上发表题为CD8+ T cell differentiation and dysfunction in cancer 的综述。本综述总结回顾了CD8+T细胞在肿瘤中的分化与功能障碍。CD8+T细胞可以选择性杀死肿瘤细胞。肿瘤相关抗原包括肿瘤因突变...
Research about intratumoural TCR repertoire demonstrated thatonly a small fraction of intratumoural CD8+ T cells (approximately 10% or less) had the capacity to recognize cancer cells. And there are cases, patients thereof, despite significant T cell infiltration into tumours, have no tumour react...
但是免疫疗法无法对大多数肿瘤患者长期有效。 近日,来自Vanderbilt-Ingram癌症中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger合作在Nature Reviews Immunology上发表题为CD8+ T cell differentiation and dysfunction in cancer的综述。本综述总结回顾了CD8+T细胞在肿瘤中的分化与功能障碍。 CD8+T细胞可以选...
免疫检查点阻断和过继T细胞治疗的临床成功证明了CD8+T细胞介导抗肿瘤反应的潜力;然而,大多数癌症患者无法获得免疫治疗的长期反应。2021年7月,Mary Philip等人在《Nat Rev Immunol》上发表了一篇题为《CD8+T cell differentiation and dysfunction in cancer》的综述,回顾了CD8+T细胞在肿瘤发生过程中向功能障碍状态的分化...
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8+ T cells to mediate an
近日,来自Vanderbilt-Ingram癌症中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger合作在Nature Reviews Immunology 上发表题为CD8+ T cell differentiation and dysfunction in cancer 的综述。本综述总结回顾了CD8+T细胞在肿瘤...
肿瘤免疫治疗:免疫检查点封锁和过继T细胞治疗的临床成功,证明了CD8+ T细胞介导抗肿瘤免疫的潜力,然而,大多数癌症患者对免疫治疗无法达到长期的有效反应。范德比尔特免疫生物学中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger一起合作,在Nature Revi...
Current BiologyZamoyska, R., 2003. T-cell differentiation: chromatin remodelling in CD4/CD8 reg- ulation. Curr. Biol. 13, 189-191.Zamoyska R (2003) T-cell differentiation: chromatin remodelling in CD4/CD8 regulation. Current Biology 13: R189-191....
CD8+ T cells are essential in the defence against viruses. Recently, peptide–HLA class I tetramers have been used to study immune responses to viruses in humans. This approach has indicated consecutive stages of human CD8+ T-cell development in acute vi
3. IL-17+ CD8+ T cell differentiation and polarisation in humans and mice It is well established that transforming growth factor (TGF)-β, IL-6, IL-1β, IL-21 and IL-23 can promote IL-17+ CD4+ T cell differentiation in humans [13], [14], [15], [16] and mice [17], [18]...