2023年1月23日,清华大学免疫学研究所董晨院士团队在《Journal of Experimental Medicine》杂志在线发表了题为“STAT3 regulates CD8+ T cell differentiation and functions in cancer and acute infection”的研究论文。该研究详细阐述了在肿瘤模型中STAT3信号通路调...
肿瘤免疫治疗:免疫检查点封锁和过继T细胞治疗的临床成功,证明了CD8+ T细胞介导抗肿瘤免疫的潜力,然而,大多数癌症患者对免疫治疗无法达到长期的有效反应。范德比尔特免疫生物学中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger一起合作,在Nature Revi...
CD8+ T-Cell Differentiation and SenescenceLaura PapagnoCelsa A SpinaArnaud MarchantMariolina SalioNathalie RuferSusan LittleTao DongGillian ChesneyAnele WatersPhilippa Easterbrook
7. Ahn, E. et al. Role of PD-1 during effector CD8 T cell differentiation. Proc. Natl. Acad. Sci. U. S. A. 115, 4749–4754 (2018).8. Buck, M. D., Sowell, R. T., Kaech, S. M. & Pearce, E. L. Metabolic Instruction of Immunity. Cell169, 570–586 (2017).
免疫检查点阻断和过继T细胞治疗的临床成功证明了CD8+T细胞介导抗肿瘤反应的潜力;然而,大多数癌症患者无法获得免疫治疗的长期反应。2021年7月,Mary Philip等人在《Nat Rev Immunol》上发表了一篇题为《CD8+T cell differentiation and dysfunction in cancer》的综述,回顾了CD8+T细胞在肿瘤发生过程中向功能障碍状态的分化...
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8+ T cells to mediate an
Purpose of reading this paper: To know the biology of T cell, especially its differentiation and function of each subgroup. However, it seems like it’s very difficult to find what I want. Maybe from a textbook? Anyway, I marked some reviews. Maybe I marked too many reviews and may not...
尽管T细胞疗法证明CD8+T细胞具有介导抗肿瘤反应的潜力，在肿瘤内也能够检测到特异性针对肿瘤细胞的CD8+T细胞。但是免疫疗法无法对大多数肿瘤患者长期有效。近日，来自Vanderbilt-Ingram癌症中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger合作在Nature Reviews Immunology上发表题为CD8+ T cell differentiation ...
CD8+ T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8+ T cell differentiation are well characterized, but the epigenetic states that underlie these changes are incompletely understood. Here, we review the ...
第三篇文章是来自Memorial Sloan Kettering Cancer Center 和Weill Cornell Graduate School of Medical Sciences的Mary Philip和Andrea Schietinger团队在Nature上发表的题为TOX is a critical regulator of tumour-specific T cell differentiation的Letter形式文章,阐述了TOX在调控肿瘤特异性T细胞(tumor-specific T cell ,...