WT or CXCR5-/- CD8+ T cells were isolated and adoptively transferred to the young and aged OT-I Rag-/- mice, which are B/T cell deficient, and mice were sacrificed 3 days after nerve injury.The results showed a robust infiltration of adoptively transferred...
2. Fernandez-Ruiz, D. et al. Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection. Immunity 45, 889–902 (2016).3. Khan, O. et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion. Nature 571, 211–218 (2019).4. ...
2. Fernandez-Ruiz, D. et al. Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection.Immunity45, 889–902 (2016). 3. Khan, O. et al. TOX transcriptionally and epigenetic...
Detection of provirus in an HTLV-I1producer CD8 T cell line by polymerase chain reactioncombinedwith digoxigenin-ELISAmethod. Jpn.J. CancerRes.1990;81:31%316.Miyamoto K, Tomita N, Ohtsuki Y, Kitajima K (1990a) Detection of provirus in an HTLV-II...
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8+ T cells to mediate antitumour responses; however, most patients wit...
T cell cells. Adoptive transfer experiments of TRMcells corroborated their potential to form circulating effector and memory cells during recall responses. Moreover, specific ablation of primary TRMcell populations substantially impaired the secondary T cell response, both locally and systemically. Thus, ...
TCF-1 and LEF-1 act upstream of Th-POK to promote CD4 T cell lineage choice and cooperate with Runx3 to silence the Cd4 gene in CD8 T cells 热度: E-protein transcription factors are required for the development of CD4 lineage T cells 热度: MicroRNA regulation of CD8 T cell ...
the formation and function of CD8+T cells can be challenged by tumors that might train a group of accomplices to resist the T cell killing. As cancer therapy stepped into the era of immunotherapy, understanding the physiological role of CD8+T cells, studying the machinery of tumor immune esca...
During chronic viral infection, CD8+ T cells develop into three major phenotypically and functionally distinct subsets: Ly108+TCF-1+ progenitors, Ly108−CX3CR1− terminally exhausted cells and the recently identified CX3CR1+ cytotoxic effector cells. Nevertheless, how CX3CR1+ effector cell dif...
T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox demands following antigen stimulation. To fulfil these needs, effector T cells must adapt to fluctuations in environmental nutrient levels at sites of infection and inf