WT or CXCR5-/- CD8+ T cells were isolated and adoptively transferred to the young and aged OT-I Rag-/- mice, which are B/T cell deficient, and mice were sacrificed 3 days after nerve injury.The results showed a robust infiltration of adoptively transferred...
(A) Prevalence of B*27/57neg LTNP/EC (n = 23, white bars) and B*27/57neg progressors (n = 13, solid gray bars) with significant IFN-γ+CD69+CD8+ T-cell responses above background to individual Gag 15-mers are shown. Trend line connects the Shannon entropy scores for each 15-...
Cancer Cell 26, 549–564 (2014).2. Fernandez-Ruiz, D. et al. Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection. Immunity45, 889–902 (2016).3. Khan, O. et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion. ...
By using HLA-A2 matched effector cells (CD8(+) T cell line or clone) and target cells supporting full HBV replication, we demonstrate that virus-specific CD8(+) T cells can inhibit HBV replication in HBV-producing hepatocytes with minimal cell lysis. Although CD8(+) T cells kill a ...
Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indigenous populations, is associated with influenza-induced mortality, although the basis for this association is unclear. Here, we define CD8+T-cell immune landscapes agains...
N. 2002. T-cell development and the CD4-CD8 lineage deci- sion. Nat. Rev. Immunol. 2:309-322.Germain, R. N. 2002. T-cell development and the CD4-CD8 line- age decision. Nat. Rev. Immunol. 2:309.Germain RN (2002) T-cell development and the CD4-CD8 lineage decision. Nature ...
©2002NaturePublishingGroup T-CELLDEVELOPMENTANDTHE CD4–CD8LINEAGEDECISION RonaldN.Germain Cell-fatedecisionsarecontrolledtypicallybyconservedreceptorsthatinteractwithco-evolved ligands.Therefore,thelineage-specificdifferentiationofimmatureCD4 + CD8 + TcellsintoCD4 + or CD8 + matureTcellsisunusualinthatitisreg...
Expansion of Protective CD8+ T-Cell Responses Driven by Recombinant Cytomegaloviruses CD8(+) T cells are critical for the control of many persistent viral infections, such as human immunodeficiency virus, hepatitis C virus, Epstein-Barr viru... U Karrer,M Wagner,S Sierro,... - 《Journal of...
Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes Here we describe an alloreactive CD3+CD4–CD8–TCRγδ-expressing, TCRαβ-negative, T-cell line that manifests MHC-linked recognition specificity for ... Louis,A.,Matis,... - 《Nature》 被引量: 326发表...
2d). To study the TCR-binding properties in the absence of CD4, we transduced the TCR-deficient CD8+ T cell hybridoma line 58α−β− with each TCR. The 58α−β− cells expressing TCRs 1 and 2 were able to bind tetramer independently of the CD4 co-receptor, whereas cells ...