By using HLA-A2 matched effector cells (CD8(+) T cell line or clone) and target cells supporting full HBV replication, we demonstrate that virus-specific CD8(+) T cells can inhibit HBV replication in HBV-producing hepatocytes with minimal cell lysis. Although CD8(+) T cells kill a ...
(1) demonstrated that CD4+CD8+ T cell F Ahmad,HS Hong,M Jackel,... - 《Journal of Virology》 被引量: 0发表: 2014年 High Frequencies of Polyfunctional CD8(+) NK Cells in Chronic HIV-1 Infection Are Associated with Slower Disease Progression Natural killer (NK) cells are effector and ...
CD4 and CD8 T cells arise in the thymus from bi-potential, CD4+CD8+double-positive (DP) progenitors. CD4/CD8 lineage choice is critical for the generation and selection of the T cell receptor (TCR) repertoire, and
To identify new A24/influenza-derived epitopes, we utilized an immunopeptidomics approach to sequence HLA-bound peptides on influenza-infected cells by liquid chromatography-tandem mass spectrometry (LC–MS/MS)24. Experiments were performed with the class I-reduced C1R B-lymphoblastoid cell line (min...
Here we describe an alloreactive CD3+CD4–CD8–TCRγδ-expressing, TCRαβ-negative, T-cell line that manifests MHC-linked recognition specificity for ... Louis,A.,Matis,... - 《Nature》 被引量: 326发表: 1987年 Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(...
ofamulticellularorganism dependsonthegenerationofthepropernumberand diversityofcelltypes.Signalsfrombroadlyexpressed receptorsthatinteractwithco-evolvedgerm-linelig- andscontrolmostdifferentiationdecisions 1 .But,adap- tiveimmunitydependsonthefunctionofTandB cells,whichexpressuniquesurfacereceptorsthatare createdby...
CD8 T cell-neuron cross-talk: a hallmark of axonal regenerative decline Author︱Luming ZhouandSimone Di Giovanni(Department of Brain Sciences, Imperial College London, Division of Neuroscience, London, United Kingdom) Editor-in-Chief︱Sizhen Wang ...
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks Hereditary cases of breast and ovarian cancer are often attributed to germ-line mutations of the BRCA1 tumor suppressor gene. Although BRCA1 is involved in... LJ Re...
(A) Prevalence of B*27/57neg LTNP/EC (n = 23, white bars) and B*27/57neg progressors (n = 13, solid gray bars) with significant IFN-γ+CD69+CD8+ T-cell responses above background to individual Gag 15-mers are shown. Trend line connects the Shannon entropy scores for each 15-...
Thus, memory CD8 T cells intrinsically express a functional FcRIIB, permitting Ag-Ab complexes to regulate secondary CD8 T cell responses. 展开 关键词: Animals Mice, Knockout Humans Mice Lymphocytic choriomeningitis virus CD8-Positive T-Lymphocytes Cell Line Lymphocytic Choriomeningitis Antigens Epitopes...