Binding of peptide/MHC (pMHC) complexes by TCR initiates T cell activation. Despite long interest, the exact relationship between the biochemistry of TCR/pMHC interaction (particularly TCR affinity or ligand off-rate) and T cell responses remains unresolved, because the number of complexes examined ...
近日,来自德国慕尼黑工业大学的Percy A. Knolle团队在Nature杂志上发表了一篇题为A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection的文章,他们证明肝窦内皮细胞(LSEC)作为肝脏“免疫变阻器”,通过与HBV病毒特异...
(2016). Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation. Cell Metab. 24, 104–117.3. Gilissen, J., Jouret, F., Pirotte, B., and Hanson, J. (2016). Insight ...
Metabolic alterations in the microenvironment significantly modulate tumor immunosensitivity, but the underlying mechanisms remain obscure. Here, we report that tumors depleted of fumarate hydratase (FH) exhibit inhibition of functional CD8 + T cell activation, expansion, and efficacy, with enhanced...
CD8 T cell-neuron cross-talk: a hallmark of axonal regenerative decline Author︱Luming Zhou and Simone Di Giovanni(Department of Brain Sciences, Imperial College London, Division of Neuroscience, London, United Kingdom)Editor-in-Chief︱Sizhen WangAssociate Editor︱Yi LuEditor︱Jiaxue Zha Aging ha...
1. Wolf, M. J. et al. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 26, 549–564 (2014).2. Fernandez-Ruiz, D. et al. Liver-resident memory CD8+ T cells form a front-...
3. M. F. Krummel, J. P. Allison, CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183, 2533–2540 (1996).4. D. R. Leach, M. F. Krummel, J. P. Allison, Enhancement of antitumor immunity by CTLA-4 blockade...
[关键词] 细胞毒性T 细胞;活化;分化;记忆T 细胞;效应T 细胞Molecular mechanism of CD8+T cell activation and differentiation LIU Chang ,WANG Hong⁃Yan .Institute of Biochemistry and Cell Biology ,Key Laboratory of Systems Biology ,Innovation Center for Cell Signaling Network ,Shanghai 200000,China ...
[6]. Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, et al. CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Cancer Discov. 2018;8(2):216-33.[7]. Rugo HS KP, Beck JT, Chisamore MJ, Hossain A, Chen Y, Tolaney SM. A phase Ib study of ...
1. Wolf, M. J. et al. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes.Cancer Cell26, 549–564 (2014). 2. Fernandez...