& Cui, W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat. Rev. Immunol. 12, 749–761 (2012). This is a review of the transcriptional pathways involved in CD8+ T cell differentiation and function during an acute immune response. CAS PubMed PubMed Central ...
T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum are short-lived cells equipped with effector machinery and more quiescent, long-lived cells with heightened proliferative potential and stem cell-like developmental plasticity. The ...
In conclusion, after intravenously administered CD3×CD19 bsAb only moderate toxicity was found, probably due to CD8 + T cell activation and cytokine release, without CD4 + T cell activation. 展开 关键词: Bispecific antibody Cytokines Phase I study Non-Hodgkin lymphoma T cell activation DOI: ...
近日,来自美国Asher Biotherapeutics公司的Ivana M. Djuretic团队在Cancer Discovery杂志上发表了一篇题为IL-2 targeted to CD8+ T cells promotes robust effector T cell responses and potent antitumor immunity的文章,他们开发了一种CD8...
MSS CRC CD8+ T cells主要标记contradictory inflammatory markers, i.e., immuno-regulation (PD-131), suppressor of T cell activity (CD3886), T cell activation (CD28, CD4487,88) and unconventional T cells (NKp4689)。 总之,观察到 MSI CRC CD8+ T 细胞暴露更多效应记忆样表面标记,而 MSS CRC ...
signalling for CD8+ T cell activation 喜欢 0 阅读量: 47 摘要: Background: Activation of both CD4+ T and CD8+ T cells is triggered by the engagement of the T cell antigen receptor (TCR) with MHC/peptide com- plexes on antigen-presenting cells. This process also requires other molecular ...
Again with our proteomic datasets, we observed that IFI35 expression was positively correlated with T cell activation and cytotoxicity [20, 21] (Additional file 1: Fig. S1A, B). Further, with the pan-cancer datasets in TCGA, the IFI35 mRNA levels were positively correlated with the CD8+ ...
Kane KP (2008) IL-15 transpresentation augments CD8 + T cell activation and is required for optimal recall responses by central memory CD8 + T cells... AI Kokaji,DL Hockley,KP Kane - 《Journal of Immunology》 被引量: 67发表: 2008年 IL-15 Transpresentation Augments CD8+ T Cell Activati...
Discusses research being done on T cell-dendritic cell (DC) interaction. Reference to a study by F. Castellino et al, published in the 2006 issue of "Nature"; Hypothesis that CD8+ T cells are recruited to DC that are activated by CD4+ T cells; Role of chemokines in the recruitment of...
Most interestingly, we also observed that CD4+ but not CD8+ T cells are able to revert significantly the exaggerated emotional response of RAG-1−/− mice. These results were not due to T-cell activation upon exposure of the mice to the behavioral paradigms (Supplementary Figure 11). The...