J. Jelinek, I. Adkins, Z. Mikulkova et al., "In vitro activation of CMV-specific human CD8+ T cells by adenylate cyclase toxoids delivering pp65 epitopes," Bone Marrow Transplantation, vol. 47, no. 2, pp. 243-250, 2012.Jelinek J, Adkins I, Mikulkova Z, et al. In vitro ...
近日，来自美国宾夕法尼亚大学的E. John Wherry带领团队在Science Immunology杂志以 In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40 发表了他们最新的研究成果，他们建立一种体外T细胞模型，能够很好的模拟慢性感染或者癌症引起的T细胞耗竭生物学功能，他们将这种...
Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activa
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. may be maintained by a population of regulatory/suppressor T cells that prevent the activation of autoreactive T cells recognizing tissue-specific antigens... A,M,Thornton,... ...
CTL, cytotoxic T lymphocytes; DC2d, 2-day monocyte-derived dendritic cells; DC7d, 7-day monocyte-derived dendritic cells; CRA, chromium-release assay; AICD, activation-induced cell death. ⁎ Corresponding author. Tel.: +1 206 667 4462; fax: +1 206 667 7983. ...
In conclusion, after intravenously administered CD3×CD19 bsAb only moderate toxicity was found, probably due to CD8 + T cell activation and cytokine release, without CD4 + T cell activation. 展开 关键词: Bispecific antibody Cytokines Phase I study Non-Hodgkin lymphoma T cell activation DOI: ...
Full CD8 T Cell Activation in Response to a Self-Antigen Expressed under the Human K14 Promoter To examine the specific response of CD8 T cells to self-antigen in the K14-OVAp model system, we employed an adoptive transfer approach Kearney et al. 1994, Kurts et al. 1996, where the do...
The Wnt pathway has a central role in stem cell regulation. Gattinoni et al. now show that activation of the Wnt signaling cascade in naive CD8+ T cells blocks their differentiation into effector T cells and triggers instead a memory stem cell–like phen
Objective:To determine the activation,proliferation,cytokine production and regulation of CD8+ T cells in PBMCs from PPD+ individuals following stimulation with BCG.Methods:PBMCs from PPD+ donors were stimulated with BCG,and cytokine production,activation and proliferation were assessed by flow cytometry...
Here the authors compare resting and IFN-α-treated islet β cells in vitro to find IFN-α inducing increased HLA-B expression, presentation of alternative epitopes, and activation of HLA-B-restricted T cells, thereby serving clues for T1D onset. Alexia Carré Fatoumata Samassa Roberto Mallone...