[6]Hong J J, Amancha P K, Rogers K, et al. Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J Immunol, 2012, 188(7): 3247-3256 [...
AlekseyV. Belikov. The role of reactive oxygen species and mitochondria in T-cellactivation. (图1) YoshihiroOhue,Hiroyoshi Nishikawa. Regulatory T (Treg) cells in cancer: Can Treg cellsbe a new therapeutic target? Cancer Sci. 2019 Jul;110(7):2080-2089.(图2) 作者:奇 诺 本文首发于“ 解...
[6]Hong J J, Amancha PK, Rogers K,et al.Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral esca...
近日,南方科技大学靳文菲课题组在iScience上发表了题为“Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq”的研究。该研究利用抗CD3/CD28磁珠刺激人静息态T细胞,并对刺激前后的样本进行单细胞转录组测序(scRNA-seq),整合公共数据从细胞亚群、基因表达、细胞-细胞通讯...
激活诱导标志物（activation-induced marker, AIM）试验利用OX40和CD25在抗原刺激后的上调现象，特别适用于在不知道确切CD4+ T细胞表位的情况下检测记忆CD4+ T细胞。此外，TCR转基因小鼠和MHC-II限制性四聚体等工具也可用于研究特定表位特异性CD4+ T细胞，但也各自存在着一些局限性。最近，随着新一代测序技术的崛起，...
[6]Martinorozco N., et al., (2009) T Helper 17 cells promote cytotoxic T tell activation in tumor immunity [J].Immunity,31(5):787-798. 开放转载 欢迎“授权”转载 欢迎转发到朋友圈和微信群。 巨噬细胞,人类免疫系统的精灵 相关科普:
During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expression...
在炎症部位,效应CD4+ Th细胞被抗原提呈细胞(APC)重新激活(Re-activation),产生效应分子。 浸润的CD4+ T细胞也可以通过其他被激活的局部免疫细胞产生的细胞因子被非特异性地激活,这一过程被称为旁观者激活。 Front. Immunol 2022 当炎症持续的状态下,记忆Th细胞会多次被重新激活,最终向CD4+CTL的分化。在获得细胞毒性...
激活诱导标志物(activation-induced marker, AIM)试验利用OX40和CD25在抗原刺激后的上调现象,特别适用于在不知道确切CD4+ T细胞表位的情况下检测记忆CD4+ T细胞。此外,TCR转基因小鼠和MHC-II限制性四聚体等工具也可用于研究特定表位特异性CD4+ T细胞,但也各自存在着一些局限性。最近,随着新一代测序技术的崛起,新的...
;三. 体液免疫应答(yìngdá)的一般规律;初次应答(yìngdá)和二次应答(yìngdá);T、B淋巴细胞活化(huóhuà)的信号转导;; ITAM 基序 (免疫(miǎnyì)受体酪氨酸激活基序) immunoreceptor tyrosine based activation motif;PTK (protein tyrosine kinase) 蛋白(dànbái)酪氨酸激酶;PLC-?;BCR信号转导与TCR信号转...