[6]Hong J J, Amancha P K, Rogers K, et al. Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J Immunol, 2012, 188(7): 3247-3256 [...
[6]Hong J J, Amancha PK, Rogers K,et al.Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral esca...
然而,肿瘤微环境(TME)中CD4+T细胞的次优活化(suboptimal activation),导致以分化不完全、细胞因子产生有限和Th亚群变化为特征的低反应状态。迁移到肿瘤中的CD4+T细胞的这种损伤使得肿瘤细胞能够逃避免疫,从而损害抗肿瘤免疫的功效。 所以,更深入地了解CD4+T细胞功能障碍的性质、影响和可恢复性,在指导治疗策略以有效地利...
During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expression...
S Valentin1, B Mathew1, S Adam-Klages1, U Bertsch1, I Lavrik2, PH Krammer2, D Kabelitz1 and O Janssen*,1 CD95 is a dual-function receptor that exerts pro- or antiapoptotic effects depending on the cellular context, the state of activation, the signal threshold and the mode of liga...
AlekseyV. Belikov. The role of reactive oxygen species and mitochondria in T-cellactivation. (图1) YoshihiroOhue,Hiroyoshi Nishikawa. Regulatory T (Treg) cells in cancer: Can Treg cellsbe a new therapeutic target? Cancer Sci. 2019 Jul;110(7):2080-2089.(图2) ...
ADAP plays a pivotal role in CD4(+) T cell activation but is only marginally involved in CD8(+) T cell activation ADAP plays a pivotal role in CD4(+) T cell activation but is only marginally involved in CD8(+) T cell activationintegrinadhesion... Podlasly,Lisa,Parzmair,... - 《...
尽管HIV治愈仍面临巨大挑战,但这一研究为开发更精准、有效的储藏库清除策略提供了重要启示。未来,结合抗原特异性激活与免疫治疗手段,可能会为HIV治愈带来新的曙光。 标题:New breakthrough in HIV cure research, antigen-specific CD4 T cell activation associated with HIV transcription. 作者:PaperplaneTH...
[6]Martinorozco N., et al., (2009) T Helper 17 cells promote cytotoxic T tell activation in tumor immunity [J].Immunity,31(5):787-798. 开放转载 欢迎“授权”转载 欢迎转发到朋友圈和微信群。 巨噬细胞,人类免疫系统的精灵 相关科普:
目的分析特发性CD4+T淋巴细胞减少症的临床特点,并探讨其发病机制和治疗. 互联网 Human Immunodeficiency Virus ( HIV ) produces a protein that prevents the activation of CD 4 + T cells. 人免疫缺陷病毒 ( HIV ) 可产生一种蛋白质,阻止CD4+T细胞的激活. 互联网 展开全部 释义 实用场景例句...