M. Gorosito Serran, J. Tosello Boari, A. Del Castillo, M. Ledesma, C. Sedlik, E. Piaggio, A. Gruppi, E.A. Acosta Rodriguez, C.L. Montes, CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8(+) T Cells, Cancer Res, 78 (2018) 115-128. ...
Human tumor CD39 + Tconv cells constituted a heterogeneous cell population with features of exhaustion, high expression of inhibitory receptors and CD107a. We found that high CD4 and ENTPD1 (CD39) gene expression in human tumor tissues correlated with a higher overall survival rate in breast ...
CD8+ T cells are critical for elimination of cancer cells. Factors within the tumor microenvironment (TME) can drive these cells to a hypofunctional state known as exhaustion. The most terminally exhausted T (tTex) cells are resistant to checkpoint block
U. et al. Defining 'T cellexhaustion’. Nat. Rev. Immunol. https://doi.org/10.1038/s41577-019-0221-9 (2019). 55. McLane, L. M., Abdel-Hakeem, M. S. & Wherry,E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu.Rev. Immunol. https://doi.org/10.1146/...
2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kallies., Enrico, Lugli., et al. (2019). Defining 'T cell exhaustion'.Nat Rev Immunol, 19(11), 0. doi:10.1038/s41577-019-0221-9 3. Jean-Christophe, Beltra., Sasikanth, Manne., Mohamed S...
CD8+ T cells in HIV control, cure and prevention. Nat Rev Immunol, 20(8), 0. doi:10.1038/s41577-020-0274-9 2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kalli...
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a ...
In addition, CD39 is also upregulated in response to chronic inflammation (e.g., tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-27, and T cell exhaustion) [10, 39, 40]. Moreover, oxidative stress and aryl hydrocarbon receptor (AHR) have been demonstrated to upregulate ...
Partially confirming recent observations correlating the CD39 expression with T-cell exhaustion, we demonstrated a divergent functional activity in CD39+ CD8+ TILs. On the one hand, CD39+ CD8+ TILs (as compared to their CD39- counterparts) produced significantly lower IFN-纬 and IL-2 amounts...
nucleotidase, is found to define tumor-infiltrating CD8+ T cell exhaustion in human cancers [12], and those tumor-infiltrating CD8+ T cells expressing CD39 could determine patients’ poor prognosis [13], [14], [15], suggesting that CD39 may be closely linked to CD8+ T cell exhaustion. ...