T cellsThe article discusses the potential therapeutic benefits of inhibiting CD38, a protein involved in immune cell metabolism, in the treatment of HIV. The authors argue that CD38 plays a role in mitochondrial dysfunction and T-cell exhaustion, both of which contribute to co...
在对T细胞亚群进行降维聚类分析后,作者注释了四个亚群,包括CD8+ T细胞、CD4+ T细胞、调节性T细胞(Tregs)和CD8+ 耗竭T细胞(图3A)。每个细胞亚群中特征基因的表达情况显示在图3B的气泡图中。CD8+ T细胞是样本中最丰富的亚群(图3C),而CD8+ 耗竭T细胞在每个样本中最为稀少。对T细胞亚群中差异表达基因的分析表明,CXC...
Higher median proportions of cell expression of HLA-DR, Ki-67, granzyme B, CLA, CCR5, and CXCR6 were observed for CD38brightCD8+ T cells compared with CD38nonbrightCD8+ T cells in patients with acute GVHD (P < .05) but not in patients without acute GVHD (P not significant). No ...
The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects. "11-0389 was used in Flow cytometry/Cell sorting to study the role of LAG-3 on T cell functionality during persistent HIV-1 infection." ...
The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects. "11-0389 was used in Flow cytometry/Cell sorting to study the role of LAG-3 on T cell functionality during persistent HIV-1 infection." ...
Tim-3 Negatively Regulates Cytotoxicity in Exhausted CD8+ T Cells in HIV Infection Cytotoxic CD8+T cells (CTLs) contain virus infections through the release of granules containing both perforin and granzymes. T cell 'exhaustion' is a hall... S Ali,M Shariq,V Bahareh,... - 《Plos One》 ...
(treatment naïve, n=28; under treatment, n=17) 18 healthy individuals were selected aimed at comprehensive analyzing the peripheral blood T lymphocyte subpopulation profile in CHB patients, and to assess their function by measuring their expression of activation/exhaustion markers (CD38, HLA-DR, ...
granulocytesand DCs in response to stimulation and can promote activation. It is also expressed by non-hematopoietic cells such as tumor cells. CD38 mediatesimmunosuppressionin tumor models by inhibiting NAD+signaling and inducingT cellexhaustion, and antagonist or depleting anti-CD38 antibody mediates ...
Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells. "56-0389 was used in Flow cytometry/Cell sorting to evaluate the direct relationship between inhibitory receptor expression and functionality in CD8 T cells." ...
in the ‘cell cycle’, ‘DNA repair’, ‘inflammation’ and ‘SASP’ pathways in ovaries from 2-month-old WT as well as 8-month-old WT andCd38−/−mice. Data are presented as the mean ± s.e.m.Pvalue was determined by the unpaired, two-tailedt-test between the two groups...