J. et al. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27, 670–684 (2007). Article CAS PubMed Google Scholar West, E. E. et al. Tight regulation of memory CD8+ T cells limits their effectiveness during sustained high viral load. Immunity 35, ...
Zhu H, Su M, Xu J, Li B, Mao R, Su Z, Zhang J. BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4+ T-cell exhaustion. Nat Commun. 2024 Feb 28;15(1):1835. doi: 10.1038...
此外,需要深入评估各种CD4+T细胞亚群对耗竭的潜在差异敏感性,以及每个CD4+T细胞亚群对抗肿瘤免疫的相对贡献。明确这些对于提高我们对CD4+T细胞耗竭及其治疗意义的理解至关重要。 参考文献: 1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234. 2. CD4 T-cell exhaustion: Does it exist and...
The central role of T cells for immunity against filariae has been shown in several studies. However, there is little knowledge about T cell exhaustion, which causes T cell dysfunction and impaired immune responses, in this group of individuals. Recently, we showed that LE patients from Ghana ...
3. Wang Yaming., Swiecki Melissa., Cella Marina., Alber Gottfried., Schreiber Robert D., Gilfillan Susan., Colonna Marco.(2012). Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cel...
and to retain their effector function against the tumor during recall challenge. These results suggest the inhibitory role of CD4+ T cells on CD8+ T-cell exhaustion without substantial effects on the differentiation of memory T cells during priming phase of the immune responses against breast ...
T. et al. Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion. Nat. Biotechnol. 37, 925–936 (2019). Article CAS PubMed PubMed Central Google Scholar Eschweiler, S. et al. Intratumoral follicular regulatory T cells curtail ...
3. Wang Yaming., Swiecki Melissa., Cella Marina., Alber Gottfried., Schreiber Robert D., Gilfillan Susan., Colonna Marco.(2012). Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection.Cell Host Microbe, 11(6), 631-...
Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown. Using two independent models, we show that CD4 T cell help enhances CD8 effector functions and prevents CD8 T cell exhaustion. We demonstrate synergy between CD4 and ...
如果大家继续看该文章《Single cell sequencing reveals trajectory of tumor-infiltrating lymphocyte states in pancreatic cancer》,除了上面的拟时序分析的图表结果描述,其实还有具体的方法学介绍。就是需要人为指定时序的起点。 生物学背景 因为T细胞的各个功能亚群(naive, memory ,effector,cytotoxic,Exhaustion)在D4和CD...