此外,需要深入评估各种CD4+T细胞亚群对耗竭的潜在差异敏感性,以及每个CD4+T细胞亚群对抗肿瘤免疫的相对贡献。明确这些对于提高我们对CD4+T细胞耗竭及其治疗意义的理解至关重要。 参考文献: 1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234. 2. CD4 T-cell exhaustion: Does it exist and...
进一步评估CD4+T细胞特异性因子对于提高我们对其耗竭机制的理解至关重要。此外,需要深入评估各种CD4+T细胞亚群对耗竭的潜在差异敏感性,以及每个CD4+T细胞亚群对抗肿瘤免疫的相对贡献。明确这些对于提高我们对CD4+T细胞耗竭及其治疗意义的理解至关重要。 参考文献: 1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 20...
进一步评估CD4+T细胞特异性因子对于提高我们对其耗竭机制的理解至关重要。此外,需要深入评估各种CD4+T细胞亚群对耗竭的潜在差异敏感性,以及每个CD4+T细胞亚群对抗肿瘤免疫的相对贡献。明确这些对于提高我们对CD4+T细胞耗竭及其治疗意义的理解至关重要。 参考文献: 1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 20...
Concurrently, kynurenine 3-monooxygenase (KMO) expression and proliferation of CD4+ T-cells were reduced, whereas exhaustion markers such as PD-L1, AHR, FOXP3, and CTLA4 were increased. Additionally, an analysis of the correlation network reconstructed using TCGA-SKCM emphasized KMO and KYNU with...
[2] Chow A, Perica K, Klebanoff C A, et al. Clinical implications of T cell exhaustion for cancer immunotherapy[J]. Nat Rev Clin Oncol, 2022, 19(12): 775-790. [3] Tay R E, Richardson E K, Toh H C. Re...
Wu J, Ma Z, Zhu H, Su M, Xu J, Li B, Mao R, Su Z, Zhang J. BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4+ T-cell exhaustion. Nat Commun. 2024 Feb 28;15(1):18...
明确这些对于提高我们对CD4+T细胞耗竭及其治疗意义的理解至关重要。 参考文献: 1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234. 2. CD4 T-cell exhaustion: Does it exist and what are its roles in cancer? Clin Cancer Res. 2021Nov 1; 27(21): 5742–5752....
early and general exhaustion (PDCD1, CTLA4, ENTPD1 ) . antigen presentation (CD74, HLA-DRB1/5, HLA-DQA2) 如果你使用上面的基因列表,你会发现主要的naive状态的是CD4的T细胞,其它主要是CD8的T细胞。 然后是: naive T cell, such as CCR7, LTB, and SELL ...
3. Wang Yaming., Swiecki Melissa., Cella Marina., Alber Gottfried., Schreiber Robert D., Gilfillan Susan., Colonna Marco.(2012). Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection.Cell Host Microbe, 11(6), 631-...
3. Wang Yaming., Swiecki Melissa., Cella Marina., Alber Gottfried., Schreiber Robert D., Gilfillan Susan., Colonna Marco.(2012). Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection.Cell Host Microbe, 11(6), 631-...