Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker CD27 are reported to be part of the memory compartment, however, only scarce data is ...
Klein U, Rajewsky K, Kuppers R: Human immunoglobulin (Ig)M+IgD+peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med. 1998, 188: 1679-1689. Article Pub...
(4). CD27 is expressed on subsets of T and B cells. The expression of CD27 is upregulated upon T cell activation. Although CD27 appears to be a marker for human memory B cells, it is only expressed in a small population of mouse B cells in germinal centers and at sites of B ...
一),memoryBcells(CD19+CD27~n1),plasmablasts(CD19+CD27~)andaveragefluores cencein— tensityofCD19wereanalyzed.andtheirrelationshipwithclinicalmanifestationsandrheum atoidfactor(RF). anti—typeIIcollagen(anti— CII),anti-cycliccitrulliantedpeptide(CCP)antibodieswereinvestigatied.Results FrequenceofnaiveB...
on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through...
Cell-surfaceCD27is a useful marker of humanmemory B cells(Agematsu et al., 2000), since essentially all circulatingCD27+B cells display hypermutated rearrangedVHgenes, while no mutations are identified in CD27−B cells. According to CD27 expression,CD19+blood B cells were grouped into CD27...
it is preferentially expressed on CD45RA+cells. In contrast, it is preferentially expressed on CD45RO+cells in the CD8+compartment. CD27 also appears to be a potential marker for memory B cells. It exists as both a disulfide‑linked dimer on the cell surface and as a soluble protei...
Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding...
on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells throu...
CD27 is considered a phenotypic marker for memory B cells and is also used to identify B regulatory (Breg) cells (3,4). It is constitutively expressed on naïve CD4 and CD8 T cells and its expression is further upregulated upon T cell activation. CD27 is on...