CD20在侵袭性癌症中的残留表达可能具有转化意义,这值得进一步的实验研究。 CD20 is the first-line diagnostic marker of B-cells, which serves as the target of the therapeutic monoclonal antibodies in B-cell lymphomas and leukemias. Recently, aberrant...
CD20在B淋巴细胞表面以寡聚体形式存在，现有实验证明CD20在B细胞表面形成的是四聚体。CD20与B细胞抗原受体（B cell antigen receptor，BCR）的膜型IgM（sIgM）存在相互作用已被被证实，B细胞活化后，BCR-CD20复合物会解离，磷蛋白、钙调素结合蛋白会暂时被招募到CD20，从而参与胞内信号的传导 [2-4]。2.2 CD20...
刚好,我检索到近期发表在组织病理学杂志的文章,要与CD30 +大B细胞淋巴瘤鉴别,具有间变性大B细胞特征,并完全丧失由滤泡性淋巴瘤引起的B细胞标志物表达。 CD30+large B cell lymphoma with anaplastic features and complete loss of B cell marker expression a...
Recent evidence has demonstrated that classical Hodgkin lymphoma (cHL) originates from mature germinal center B cells. However, only approximately 25% of cHLs express the classical B-cell marker CD20. There is very little, and controversial, information on the prognostic significance of Immunophenotypin...
CM Howard,S Anderson,B Harrington - 《Journal of Veterinary Diagnostic Investigation》 被引量: 0发表: 2024年 Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry These exosomes also expressed the B cell marker CD20, and the complement inhibitory...
CD20在B淋巴细胞表面以寡聚体形式存在,现有实验证明CD20在B细胞表面形成的是四聚体。CD20与B细胞抗原受体(B cell antigen receptor,BCR)的膜型IgM(sIgM)存在相互作用已被被证实,B细胞活化后,BCR-CD20复合物会解离,磷蛋白、钙调素结合蛋白会暂时被招募到CD20,从而参与胞内信号的传导 [2-4]。
B malignanciesEBV transformationCLLBackground CD20 is a B cell lineage–specific marker expressed by normal and leukemic B cells and targeted by several antibody immunotherapies. We have previously shown that the protein from a CD20...doi:10.1186/s40164-016-0036-3Clémentine Gamonet...
Rituximab,a chimeric monoclonal antibody targeted against the pan-B-cell marker CD20. Mechanisms of cell destruction that have been demonstrated to be activated by rituximab binding to CD20 include direct signaling of apoptosis,complement activation and antibody dependent cellular cytotoxicity. Rituximab is...
CD20+ B Cell Depletion Alters T Cell Homing Depleting mAbs against the pan B cell marker CD20 Laman,D J.,Tak,... - 《Journal of Immunology Official Journal of the American Association of Immunologists》 被引量: 14发表: 2014年 Characterization of angioimmunoblastic T-cell lymphomas (AILT) ...
CD20(Cluster of Differentiation 20)是一种跨膜磷蛋白,位于B淋巴细胞表面。B淋巴细胞是由骨髓内多能干细胞分化而成,其发育经过祖B细胞(Pro-B),前B细胞(Pre-B),不成熟B细胞(Immature B)以及成熟B细胞(Mature B)几个阶段。成熟B细胞被释放至淋巴组织,可继续分化为浆细胞(Plasma Cell)。CD20作为B细胞的表面抗...