CD24, also known as heat stable antigen (HSA), is a heavily and variably glycosylated 35‑60 kDa GPI-linked sialoprotein that is expressed on B cells, T cells, keratinocytes, and myofiber synaptic nuclei and is up‑regulated in a wide variety of cancers. It is also a marker for exoso...
CD24 may play a role in the regulation of B cell proliferation and differentiation. CD24 is expressed in hematological malignancies as well as in a large variety of solid tumors. A shift from apical localization to cytoplasmic staining of CD24 is a surrogate marker of stromal invasion in ...
CD24最初被认为是B细胞的标记物，在B细胞分化早期阶段表达，同时对淋巴细胞成熟、神经系统发育及生理状态下的组织更新起到重要的作用。CD24主要表达于造血系统的细胞、神经组织以及一些特定的上皮细胞，同时也见于大多实体肿瘤、炎症组织以及自身免疫性疾病的某些细胞。众多研究发现，CD24在生理与病理状态下具有完全相反...
CD24, also known as heat stable antigen (HSA), is a heavily and variably glycosylated 35‑60 kDa GPI-linked sialoprotein that is expressed on B cells, T cells, keratinocytes, and myofiber synaptic nuclei and is up‑regulated in a wide variety of cancers. It is also a marker for exoso...
J Cell Biochem 45: 156 – 161 Pirruccello SJ, Lang MS (1990) Differential expression of CD24-related epitopes in mycosis fungoides/Sezary syndrome: a potential marker for circulating Sezary cells. Blood 76: 2343 – 2347 Pirruccello SJ, LeBien TW (1986) The human B cell-associated antigen ...
neural cells, and epithelial cells. CD24 is widely used to delineate stages of lymphocyte development (1-3). It also binds to Siglec-10 in humans or Siglec-G in mice (4,5). CD24 is frequently used as a marker to identify and isolate cancer stem cells in various cancer types (6,7)...
We recently identified the SCLC surface antigen Cluster-4 (CL-4) to be identical to the B cell differentiation marker CD24, except for one amino acid residue. The CD24/CL-4 antigen is highly expressed on SCLC, but rarely on NSCLC cells. In order to investigate the influence of the ...
CD24最初被认为是B细胞的标记物,在B细胞分化早期阶段表达,同时对淋巴细胞成熟、神经系统发育及生理状态下的组织更新起到重要的作用。CD24主要表达于造血系统的细胞、神经组织以及一些特定的上皮细胞,同时也见于大多实体肿瘤、炎症组织以及自身免疫性疾病的某些细胞。众多研究发现,CD24在生理与病理状态下具有完全相反的...
CD24 is expressed in B cells until their terminal differentiation into plasma cells. It has been used widely as a marker to fractionate different B-lineage differentiation stages. CD24 has been found on a variety of other hematopoietic and neural cell types and is now classified as a costimulat...
In this study, we used single-cell mass cytometry and adoptive transfer of B cell subtypes to NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice to identify B27+IgM+CD24hi cells as the major producers of IgMOSE in humans. Notably, these cells have characteristics of human circulatory marginal ...