CD19 is the broadest lineage specific marker for B cells and functions as a B-cell co-receptor in conjunction with CD21 (Bradbury et al. 1992), CD9, CD81 and CD82 (Horváth et al. 1998). CD19 is implicated in the down-regulation of B cell growth and proliferation (Pezzutto et al...
However, CD19, another B cell marker, is more widely expressed and has emerged as a promising target in autoimmune diseases. CD19-targeted therapies, such as CAR T cells and Uplizna (inebilizumab), have demonstrated potential in treating refractory autoimmune diseases, including SSc....
cellleve1.FrequenceofnaYveBcells (CD19CD27 一),memoryBcells(CD19+CD27~n1),plasmablasts(CD19+CD27~)andaveragefluores cencein— tensityofCD19wereanalyzed.andtheirrelationshipwithclinicalmanifestationsandrheum atoidfactor(RF). anti—typeIIcollagen(anti— ...
周细胞是CD19 CAR-T神经毒性的靶细胞 斯坦福大学等2020年在Cell上发表文章(文献3),通过单细胞测序发现,发现在大脑的周细胞(pericytes/ Mural Cells)表达CD19(通过CD248作为marker标记周细胞),是CD19 CAR-T产生off-tumor神经毒性的靶细胞。 可能机制:周细胞是血脑屏障的重要组成细胞,CAR-T治疗引起的细胞因子释放...
The FMC7 antibody detects a glycoprotein of 105 kD found on circulating B-lymphocytes. Studies on normal lymphocytes, leukaemic cells and cell lines indicate that FMC7 is marker for a limited segment of the B cell maturation pathway. This glycoprotein is expressed in varying degrees on normal ci...
Peripheral CD19+ cell counts and therapy intervals as a surrogate marker for B-cell depleting therapy in multiple sclerosis and neuromyelitis optica (P1.400) J Bolz,M Peschke,L Dehyung,... 被引量: 0发表: 2017年 Peripheral CD19+B-cell counts and infusion intervals as a surrogate for long...
CD19 MicroBeads were developed for positive selection or depletion of CD19+ B cells from different cell sources such as human PBMCs, bone marrow, lymphoid tissues, or cell cultures. | Miltenyi Biotec | 中国
This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. ...
CD19 is a pan B cell marker that is recognized as an attractive target for antibody-based therapy of B-cell disorders including autoimmune disease and hematological malignancies. The object of this study was to stably express the human CD19 antigen in the murine NIH-3T3 cell line aimed to be...
筛选标记(Selection Marker) Puromycin (5 μg/mL) 培养基(Culture Medium) DMEM medium + 10% FBS 冻存液(Freeze Medium) 10% DMSO + 90% FBS 装量(Quantity) 1 vial contains at least 5x10^6 cells in 1 ml of 10% DMSO in FBS. 存储(Storage) ...