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Learn about BLINCYTO®, a treatment for CD19-positive MRD(+), R/R, and consolidation B-cell precursor ALL. See Full Safety Info, including Boxed Warning.
本研究首次证实了CD19-PD-1/CD28-CART在PD-L1+大B细胞淋巴瘤患者中的耐受性、安全性和令人鼓舞的疗效,值得通过大规模、多中心临床试验进行进一步的证实和推广。 参考文献 CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effecti...
先前的研究显示,靶向CD19的CAR-T细胞疗法在急性B细胞淋巴细胞白血病患者中的缓解率为68%～93%,在CLL患者中为57%～71%,在非霍奇金淋巴瘤患者中为64%～86%。 Rezvani等的研究纳入11例复发或难治性非霍奇金淋巴瘤或CLL患者[中位年龄60岁,男性7例; 既往治疗中位线数为4(范围3-11)],给予脐带血来源的HLA不匹...
参考文献 CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effective in Patients with PD-L1 Positive B-Cell Lymphoma.Clin Cancer Res.2020.Online ahead of print. 合作单位汇总,一并致谢 协作- 共享 - 进步
Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes. Nat Rev Immunol. 2013;13:118–32. Article CAS PubMed PubMed Central Google Scholar Hitoshi Y, Yamaguchi N, Mita S, Sonoda E, Takaki S, Tominaga A, et al. Distribution of IL-5 receptor-positive B cells. ...
UNII号 TYR224OK86 化学名 CD19 POSITIVE CELLS 结构式图片 ITIS 180092 NCBI 9606 扩展信息 PubChem(物化性质) ITIS VIP试用医疗器械查询APP下载客服中心常见问题数据可视化数据分析挖掘系统网站地图业务介绍友情链接 400-678-0778 投诉热线: (023) 6262 8397 邮箱: tousu@yaozh.com QQ: ...
图1. 小鼠 CD19+ 细胞富集分选试剂盒分选流式图 用小鼠CD19+细胞分选试剂盒分离小鼠脾细胞中的CD19+细胞。利用Anti-Mouse CD3e FITC (货号xxxxxx)和Anti-Mouse CD45R (B220) APC (货号xxxxxx)标记细胞,对分选前(左)或分选后(右)的细胞进行流式分析。
相关研究结果发表在2020年2月6日的NEJM期刊上,论文标题为“Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors”。 在参与这项临床研究的11名患者中,8人(73%)对治疗作出反应,其中7人完全缓解,这意味着他们在中位随访13.8个月时不再显示疾病迹象。缓解后的治疗是对其中的5名有反应的...
The infused CAR-NK cells expanded and persisted at low levels for at least 12 months. 输入的CAR-NK细胞发生扩增,并以低水平持续至少12个月。 CONCLUSIONS Among 11 patients with relapsed or refractory CD19-positive cancers, a majority had a response to treatment with CAR-NK cellswithout the develo...