MacrophageProliferative glomerulonephritisAcute kidney injuryCD163, a marker of M2 macrophages, possesses anti-inflammatory properties. This study aims to investigate the clinicopathological significance of CD163-positive macrophages in proliferative glomerulonephritis.Renal tissue samples from patients with lupus ...
[关键词] CD163;M2 型巨噬细胞;肿瘤相关巨噬细胞;肿瘤Research progress of M2 macrophage marker CD163 and tumorDING Ting-Ting,PAN Hong-Fei,ZHANG Hong,LONG Run-Ying,LUO Jun-Min,FENG Ji-Hong. Department ofAbdominal Oncology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003,China[Abstract...
Therefore, the downregulation of CD163 expression is a crucial factor in the transformation of M2 macrophages to M1. Additionally, increased levels of circulating soluble CD163 have been considered as a specific marker of macrophage activation [36]. LPS and phorbol 12-myristate 13-acetate have ...
CD163is a monocyte/macrophage specificmembrane markercleaved from thesurfaceof activated macrophages as a soluble form (sCD1639) when inflammation of theCNSoccurs. sCD163 can be detected in blood andCSF[59]. Fabriek et al.[212]found an up-regulation of plasma sCD163 and a down-regulation of...
CD163 was first identified as a macrophage-specific scavenger receptor for Hb:Hp complexes5. In addition to its membrane bound form, a soluble variant of CD163 (that is, sCD163) exists in the plasma as well as other tissue fluids. sCD163 demonstrates relatively low affinity for Hb:Hp as...
CD163 is used as a surface marker of M2 type macrophages, including M2 type tumor-associated macrophages (TAMs), which facilitate cancer progression by secreting cytokines to promote angiogenesis, immunosuppression, and metastasis (3). Inflammatory stimulation and stress signals can induce extracellular ...
mouse CD163 is not as readily induced by M2 polarizing cytokines, and it is not a good marker of M2 macrophages. No common cell lines of monocytic or macrophage origin express mouse CD163. Unlike in mouse, in Human CD163 has been shown to be proteolytically cleaved from the...
As a marker of M2-polarized macrophages, CD163 is implicated in tissue repair, immune regulation, and resolution of inflammation. Its soluble form (sCD163), shed by ADAM17-mediated cleavage, serves as a biomarker for macrophage activation in conditions like sepsis, atherosclerosis, and chronic li...
CD68 is a pan-macrophage marker frequently used as a marker for TAMs, and CD68 recognizes both tumoricidal M1 and anti-inflammatory M2 macrophages. CD163, a marker of M2 macrophages, has been studied in several aggressive tumors, and the increased expression of CD163 was significantly associated...
Macrophages are regulators of inflammation and play a role in obesity, lipid metabolism and insulin resistance (IR). The present study was designed to assess macrophage activation, reflected by serum soluble CD163 (sCD163), in renal transplant recipients (RTR) and its relation to chronic allograft...