K. (2006). The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants. J Leukoc Biol 79, 837-845.Nielsen, M. J., M. Madsen, H. J. Moller, and S. K. Moestrup. 2006. The macrophage
11,12 However, once plasma Hp is depleted, CD163-mediated uptake of free Hb is maintained through an apparently lower-affinity, Hp-independent interaction between free Hb and the macrophage scavenger receptor CD163. Materials and methods Cell culture Human embryonic kidney cells (HEK293; Invitrogen...
CD163 and CD91 are scavenging receptors with highly increased expression during the differentiation of monocytes into the anti-inflammatory macrophage phenotype. In addition, CD91 is expressed in monocyte-derived dendritic cells (MoDCs), where the receptor is suggested to be important for internalizatio...
CD163 (a monocyte/macrophage-specific scavenger receptor)98and LRP1 (LDL receptor related protein 1),99heme-hemopexin and hemoglobin-haptoglobin complexes are internalized via endosomes, after which the rate-limiting enzyme heme oxygenase-1 (HO-1) catabolizes heme to produce biliverdin, releasing ir...
Macrophage subsets in the human ileum. Lin− (CD3, CD19, CD20, CD56, TCRαβ), live (PI−) singlet cells were identified in digests of resected healthy ileum (n=8) and CD45+ cells purified by magnetic antibody cell sorting. (a) CD14hi and CD14lo cells were identified and HLA-DR...
Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res. 2004;94:119–26. Article CAS PubMed Google Scholar ...
Workshop cluster 1 (WC1) is a member of the scavenger receptor cysteine-rich (SRCR) superfamily that includes CD5, CD6, CD163, and M160. Bovine WC1 consists of 11 SRCR domains, a unique domain 1, and two homologous 5 SRCR domain cassettes, WC1 domains 2-6 and 7-11. The porcine...
Podrez, E. A., Febbraio, M., Sheibani, N., Schmitt, D., Silverstein, R. L., Hajjar, D. P., Cohen, P. A., Frazier, W. A., Hoff, H. F., and Hazen, S. L. (2000) Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nit...
The macrophage marker, CD163, is a putative receptor for African swine fever virus (ASFV). Pigs possessing a complete knockout of CD163 on macrophages were inoculated with Georgia 2007/1, a genotype 2 isolate. Knockout and wild type pen mates became infected and showed no differences in ...
Recently, CD163, a monocyte/macrophage-specific scavenger receptor for hemoglobinhaptoglobin complex, was reported to be expressed in the CNS by perivascular macrophages but not by resident microglia in human brain. The inventors utilized this disparity in the expression pattern of CD163 by ...