CD163+ macrophages were primarily found in shoulder regions and in the center of the plaques. The present data show that CD163 is associated with increased plaque vulnerability in human carotid plaques, supporting the notion that CD163+ macrophages could contribute to clinical events....
已经表明,VEGFR2活化可以激活和降解VE-钙粘蛋白,从而产生血管通透性。郭先生等(Guo L, Akahori H, Harari Eet alCD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.J Clin Invest2018;128: 1106–24.)显示CD163 +巨噬细胞通过VEGF / VEGFR2与VE-钙粘...
Am J Surg Pathol. 2005 May;29(5):617-24. Lau SK, Chu PG, Weiss LM.CD163: a specific marker of macrophages in paraffin-embedded tissue samples.Am J Clin Pathol. 2004 Nov;122(5):794-801.
CD11c is a type Itransmembrane proteinthat is expressed on monocytes,granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia. The amount of this antigen is varied with the...
(TNFlike weak inducer of apoptosis) and can function as an erythroblast adhesion receptor (4, 8, 10). The macrophage scavenger receptor CD163, which is upregulated in a number of inflammatory and malignant diseases, is a promising target on macrophages in anti-inflammatory and anti-...
Figure 1. CD163 expression in macrophages.Balb/c splenocytes and resident peritoneal exudate cells were Fc blocked, stained with anti-mouse CD163 (clone TNKUPJ), and co-stained with anti-mouse F4/80 eFluor 450 (clone BM8) and anti-mouse CD11b APC (clone M1/70). Althou...
CD163 基因功能 The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin comp...
Furthermore, during POD24, more CD8+ T cells in proximity to FL cells were found interacting with macrophages rather than regulatory T cells (Tregs). There was also an observed increase in the cooperation between macrophages and Tregs, which collectively worked to subdue cytotoxic T cell activity...
不过, 这个并不是最严重的, 因为这个文章做的的是脑部区域的单细胞,其实还需要考虑一下巨噬细胞这个时候是不是得更名为小胶质细胞。 虽然m1和m2的分类深入人心: pro-inflammatory M1 macrophages, which are thought to oppose tumor progression, tissue reparative M2 macrophages, which promote tumor growth and ...
不过, 这个并不是最严重的, 因为这个文章做的的是脑部区域的单细胞,其实还需要考虑一下巨噬细胞这个时候是不是得更名为小胶质细胞。 虽然m1和m2的分类深入人心: pro-inflammatory M1 macrophages, which are thought to opposetumor progression, tissue reparative M2 macrophages, which promote tumor growth andmeta...