Ubiquitination controls the function of target proteins through a series of reactions involving E1-activating, E2-conjugating, and E3-ligating enzymes1. The E3 family of membrane-associated RING-CH (MARCH) E3 ligases regulates key immunoreceptors including major histocompatibility complex class II (MHC ...
Unlike the collection of BM cells from patients with MM, serum samples are easy to collect sequentially, and sCD86 is a marker that can be easily measured. Therefore, serum sCD86 could be a useful prognostic indicator in newly diagnosed patients with MM. To elucidate the relationship between ...
Although plentiful studies described CD86 and CD206 as a cell surface immune marker of M1 and M2 macrophage respectively, only a few reports emphasized the clinic significance of CD86+ and CD206+ TAMs in tumors. In colorectal cancer, the infiltration of CD86+ TAMs indicated a favorable prognosis...